【摘要】 目的比较含微生态制剂的四联疗法与标准四联疗法治疗顽固性幽门螺杆菌(Hp)感染的临床疗效和安全性。方法 80例顽固性Hp感染患者,按照随机数字表法分为观察组和对照组,各40例。对照组:采用标准四联疗法:雷贝拉唑+甲硝唑+阿莫西林+胶体果胶铋;观察组采用含微生态制剂的四联疗法:雷贝拉唑+甲硝唑+阿莫西林+金双歧(双歧杆菌乳杆菌三联活菌片);两组均治疗14 d,观察治疗不良反应发生情况。1个月后复查胃镜行快速尿素酶(Urease)试验和碳14呼气试验,对比两组的Hp根除情况。结果观察组和对照组的Hp根除率分别为92.5%、92.5%,两组比较差异无统计学意义(P>0.05);观察组和对照组不良反应发生率分别为5.0%、15.0%,观察组明显低于对照组,差异具有统计学意义(P<0.05)。结论含有微生态制剂的四联疗法根治顽固性Hp感染疗效与标准四联疗法相当,但其不良反应少,值得临床推广应用。更多还原

【Abstract】 Objective To compare the clinical effect and safety between quadruple therapy containing probiotics and standard quadruple therapy in the treatment of intractable helicobacter pylori(Hp) infection. Methods A total of 80 intractable Hp infection patients were divided into observation group and control group by random number table, with 40 cases in each group. The control group received standard quadruple therapy: rabepra zole+metronidazole+amoxicillin+colloidal bismuth pectin. The observation group was treated by quadruple therapy containing probiotics: rabeprazole+metronidazole+amoxicillin+golden bifid(bifidobacterium lactobacillus sanlian living bacterium tablets). The therapy lasted for 14 d in the two groups, and adverse reactions during the therapy were observed. Reexamination was taken after 1 month for gastroscope rapid urease test and carbon 14 breath test, and the situation of Hp eradication was compared between the two groups. Results The Hp eradication rates of the observation group and the control group were 92.5% and 92.5%, and the difference between the two groups had no statistical significance(P>0.05). The incidences of adverse reactions of the observation group and the control group were 5.0% and 15.0%, which was obviously lower in the observation group than in the control group. The difference had statistical significance(P<0.05). Conclusion The curative effect by quadruple therapy containing probiotics is similar with that by standard quadruple therapy in treating intractable Hp infection, while the former has few adverse reactions. It is worthy of clinical promotion and application.更多还原