【摘要】 目的探讨绝经前、后乳腺癌患者临床病理因素、血清3144 m/z蛋白峰表达水平的差异以及这些因素对乳腺癌患者生存的影响。方法用SELDI-TOF-MS技术检测术前乳腺癌患者血清3144 m/z蛋白峰的表达水平,对513例乳腺癌患者进行临床病理资料分析。结果绝经前、后乳腺癌患者血清3144 m/z蛋白峰阳性率分别为28.9%、32.7%,3144 m/z蛋白峰表达阳性的绝经后组乳腺癌患者预后最差,差异有统计学意义(P<0.05);绝经前组乳腺癌患者3144 m/z蛋白峰表达阳性和阴性的患者预后差异无统计学意义(P>0.05)。Cox多因素分析发现3144 m/z蛋白峰表达阳性是绝经后乳腺癌患者的独立预后因素,而绝经前乳腺癌患者预后主要与PR受体状态有关。绝经前后乳腺癌患者激素受体阳性率、妊娠次数以及流产史差异有统计学意义(P<0.05)。结论血清蛋白峰3144 m/z更适于监测绝经后乳腺癌患者的预后。更多还原

【Abstract】 Objective To investigate the differences of clinical- pathological factors,and serum protein peak 3144 m / z levels in pre- and post- menopausal breast cancer,as well as the impact of these variants on survival. Methods The expression level of protein peak 3144 m / z was detected before surgery with SELDI- TOF- MS,and the clinical pathological data of 513 patients with breast cancer was analyzed. Results The positive rates of 3144 m / z protein peak were respectively 28. 9% and32. 7% in pre- and post- menopausal breast cancer patients. The prognosis of patients with breast cancer in post- menopausal women with positive expression of 3144 m / z protein was the worst,and the difference had statistically significant( P < 0. 05),and there was no statistical significance on the difference in the expression of serum protein peak 3144 m / z in patients with breast cancer in the pre- menopausal group( P > 0. 05). Serum protein peak 3144 m / z was an independent prognostic factor on multivariate Cox regression analysis of post- menopausal breast cancer patients. Hormone receptor expression levels were associated with overall survival in pre- menopausal breast cancer patients. The positive rate of hormone receptor,the number of pregnancy and the history of abortion were different in the patients with breast cancer pre- and post- menopausal,and the difference had statistical significance( P < 0. 05). Conclusion Serum protein peak 3144 m / z is more suitable for monitoring the prognosis of post- menopausal breast cancer patients.更多还原