【摘要】 目的探讨多西紫杉醇、顺铂、5-氟尿嘧啶与多西紫杉醇、顺铂联用后给予希罗达单药维持治疗晚期胃癌的临床效果及安全性比较。方法选择本院75例晚期胃癌患者作为研究对象,随机分为观察组(多西紫杉醇、顺铂、希罗达,n=38)和对照组(多西紫杉醇、顺铂、5-氟尿嘧啶,n=37)。通过近期疗效和远期临床效果如无进展生存(PFS)、治疗失败时间(TTF)和总生存时间(OS)等,以及毒副反应统计情况比较2组的疗效与不良反应情况。结果观察组的近期临床总有效率为52.6%,与对照组59.5%差异无统计学意义(P>0.05)。观察组和对照组的近期临床控制率分别为94.7%和86.5%。观察组在PFS和TTF时间上略好于对照组,但在OS上略低于对照组,各项指标比较2组差异均无统计学意义(P>0.05)。结论多西紫杉醇、顺铂联用后给予希罗达单药维持治疗效果肯定,副作用少,且无进展生存期较长,值得推广和应用。更多还原

【Abstract】 Objective To discuss and compare the clinical effects and safety of docetaxel / cisplatin /5- fluorouracil and docetaxel / cisplatin / xeloda on the treatment of advanced gastric cancer. Methods 75 cases of advanced gastric cancer patients in our hospital were selected and randomly divided into two groups( observation group with docetaxel / cisplatin / xeloda,n = 38)and control group( control group with docetaxel / cisplatin /5- fluorouracil,n = 37). Both short- term,long- term clinical efficacy and effectiveness,such as progression- free survival( PFS),time to treatment failure( TTF) and overall survival( OS)and toxicities reaction were recorded to compare the efficacy and adverse reactions between two groups. Results Total clinical effect of observation group in short term was 52. 6%,while that of control group was 59. 5% with no significant difference( P >0. 05). The clinical control rate in short term for observation group and control group were 94. 7% and 86. 5%,respectively.PFS and TTF of observation group was a little bit better than control group,but with slightly lower OS. There was no statistical difference on all index between two groups. Conclusion The maintenance treatment effects of docetaxel / cisplatin / xeloda was confirmed with few side effects and longer PFS,worthy of promotion and application.更多还原