【摘要】 【目的】探讨肿瘤标志物CA19-9与子宫内膜癌临床病理因素的关系。【方法】收集2000-2010年广东省子宫内膜癌防治项目协作医院的子宫内膜癌病例,对术前检查血清CA19-9并行分期手术者2 342例进行回顾性分析。【结果】Ⅰ、Ⅱ、Ⅲ和Ⅳ期子宫内膜癌的术前血清CA19-9阳性率分别为17.4%、32.9%、39.5%和44.3%。随着分期的增加,CA19-9阳性率升高(P<0.05)。单因素分析显示,术前血清CA19-9阳性与组织学类型不相关(P>0.05);术前血清CA19-9阳性与组织学分级、肌层浸润深度、腹水细胞学阳性、宫颈间质浸润、淋巴脉管间隙受累、附件转移、淋巴结转移相关(P<0.05)。多因素分析显示组织学低分化、深肌层浸润、宫颈间质浸润、手术病理分期晚期是术前血清CA19-9阳性的独立影响因素(P<0.05)。【结论】术前血清CA19-9水平的变化是预测子宫内膜癌病理高危因素的一个有价值的指标。更多还原

【Abstract】 【Objective】 The aim of this study was to explore the relationship between CA19-9 and clinicopathological characteristics in endometrial cancer. 【Methods】 2342 patients source from cooperative? hospitals for endometrial cancer prevention and control project with surgically treated endometrial carcinoma preoperatively evaluated with serum levels of CA19-9 were included in this retrospective study. 【Results】 The serum CA19-9 positive rates in endometrial cancer increased with stages which were17.4%, 32.9%, 39.5% and 44.3% for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively(P < 0.05). Univariate analysis revealed that positive serum CA19-9 not related with histological type(P > 0.05), but related with tumor grade, deep myometrial invasion, abdominal dropsy cytology, cervical stroma involvement, lymph-vascular space invasion, adnexal metastasis and lymph node metastasis(P <0.05). Multivariate analysis revealed that poorly differentiated, deep myometrial infiltration, cervical involvement and advanced cancer related with positive serum CA19-9(P < 0.05). 【Conclusions】 preoperative serum CA19-9 level was a valuable index in prediction pathological high risk factors of endometrial cancer.更多还原