【摘要】 目的探讨精神分裂症患者血清胰岛素样生长因子2(insulin-like growth factor-2,IGF-2)水平变化及其与临床特征的关系。方法纳入精神分裂症患者51例(患者组)和健康志愿者50名(对照组),采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评估患者的精神症状,连线测试A(trail making test A,TMTA)、数字符号编码测验(digit symbol coding subtest,DSCT)、持续操作测验(continuous performance test,CPT)和Stroop色词测验(Stroop color-word test,SCWT)评估两组的认知功能,使用酶联免疫吸附法测定两组血清IGF-2水平。结果患者组与对照组TMTA、DSCT、CPT和SCWT测试结果均存在统计学差异(P<0.05)。患者组血清IGF-2水平低于对照组[(202.7±40.7)ng/m L vs.(365.9±65.5)ng/m L],差异有统计学意义(P<0.01);首发和复发患者血清IGF-2水平无统计学差异(P>0.05)。患者血清IGF-2水平与PANSS阴性症状分(r=-0.397,P=0.004)、CPT分值(r=0.378,P=0.006)、SCWT单词总数(r=0.289,P=0.040)、SCWT颜色总数(r=0.327,P=0.019)、SCWT色/词总数(r=0.386,P=0.005)的相关性具有统计学意义。结论精神分裂症患者血清IGF-2水平下降与阴性症状和认知损害有关,提示IGF-2参与该病发病过程,可能是评价疾病严重程度的生物学指标。更多还原

【Abstract】 ObjectiveTo explore the change of serum insulin-like growth factor-2(IGF-2) and its relationship with clinical characteristics in patients with schizophrenia.MethodsFifty-one schizophrenic patients were recruited in the present study and 50 healthy volunteers served as controls. The serum IGF-2 level was measured using enzyme linked immunosorbent assay(ELISA). Positive and Negative Syndrome Scale(PANSS) was used to evaluate the psychotic symptoms of patients. Trail Making Test-A(TMTA), Digit-Symbol Coding Test(DSCT), Continuous Performance Test(CPT)and Stroop Color-Word Test(SCWT) were used to evaluate the cognitive function of both groups.ResultsThere were significant differences in the results of TMTA, DSCT, CPT and SCWT between patient and control groups. The serum levels of IGF-2 were significantly lower in patients than that in controls [(202.7±40.7) ng/m L vs.(365.9±65.5) ng/m L, P<0.01].The levels of serum IGF-2 were not significantly different between first-episode and recurrent schizophrenic patients(P>0.05). Furthermore, significant correlations were found between the serum IGF-2 level and the negative symptom subscale of PANSS(r=-0.397, P=0.004), CPT score(r=0.378, P=0.006), SCWT-word number(r=0.289, P=0.040), SC-WT-color number(r=0.327, P=0.019) and SCWT-word/color number(r=0.386, P=0.005) in schizophrenic patients.ConclusionThe serum IGF-2 levels of patients with schizophrenia are significantly lower than that of healthy controls, and the IGF-2 level is associated with the severity of negative symptoms and cognitive impairments in patients, indicating that serum IGF-2 might be an indicator of the severity of schizophrenia.更多还原