【摘要】 目的探讨白细胞介素(IL)-6对乙型肝炎病毒(HBV)相关原发性肝细胞癌(PHC)的临床诊断价值。方法选择2008年5月至2012年6月南通市第三人民医院收治的36例HBV相关PHC及32例HBV相关肝硬化患者为研究对象,采用酶联免疫吸附试验检测血清IL-6表达水平,分析其与甲胎蛋白(AFP)的相关性及对HBV相关PHC发生的判断。结果 HBV相关PHC患者血清IL-6表达水平显著高于肝硬化患者,肝硬化患者高于健康对照组(t=6.442、6.069,P均=0.000);血清IL-6与AFP呈正相关关系(r=0.262、P=0.047),二者预测HBV相关PHC发生ROC面积分别为0.859和0.904;二者均能较好预测HBV相关PHC发生(Z=7.917、10.008,P均=0.000);以血清IL-6和AFP为参数,拟合预测HBV相关PHC发生的Logistic二元回归方程,模型方程拟合优度高(χ2=0.434、P=0.999),准确率达89.7%。结论 IL-6在预测HBV相关PHC发生方面与AFP具有同等临床价值,若将两者联合作为预测HBV相关PHC发生的指标,则具有更高的准确性。更多还原

【Abstract】 Objective To explore the clinical value of interleukin(IL)-6 for hepatitis B viurus(HBV) related primary hepatocellur carcinoma(PHC). Methods Total of 36 patients with HBV related PHC in the Third Hospital of Nantong, from May 2008 to June 2012 were collected, among whom, 32 patients with HBV related liver cirrhosis and 20 healthy controls were enrolled. IL-6 was detected by ELISA. The relationship between IL-6 and AFP and their predicting value for the happening of HBV related PHC were analyzed, respectively. Results The level of serum IL-6 in the patients with HBV related PHC was higher than that in HBV related liver cirrhosis and healthy controls(t = 6.442, 6.069; P = 0.000). There was positive correlation between IL-6 and AFP(r = 0.262, P = 0.047). The area under the ROC curve of IL-6 and AFP predicting HBV related PHC were 0.859 and 0.904, respectively(Z = 7.917, 10.008; P = 0.000). When IL-6 and AFP were both taken as parameters predicting occurrence of HBV related PHC, the Logistic binary regression equation had high goodness-of-fitting(χ2 = 0.434,P = 0.999), the accuracy was 89.7%. Conclusions IL-6 and AFP have the equivalent clinical value for predicting HBV related PHC. If taken them as predictors together, they had very high accuracy.更多还原