【摘要】 柚皮苷是从中药化橘红中提取、分离、纯化得到的有效单体,本团队历时10余年将其开发成国内外首创的一类新药,已获得新药临床批件。综述了柚皮苷药理作用及机制研究、非临床药代动力学研究、毒理学研究等临床前研究概况。更多还原

【Abstract】 Naringin is a pharmacologically active compound extracted and purified from Citri Grandis Exocarpium( Huajuhong). During the past more than ten years,naringin has been developed into a classⅠinnovative drug to treat cough by our group. The Drug Clinical Trial Approval of naringin was issued by China Food and Drug Administration. As such,this review aims to summarize all of pre-clinical studies of naringin from our laboratory,including pharmacological effects and acting mechanisms,non-clinical pharmacokinetics and toxicological evaluation.更多还原