【摘要】 为了研究珊瑚内生细菌Pelomonas puraquae sp.nov(B-2)次生代谢产物,采用现代分离纯化方法对其发酵液和菌丝体的次生代谢产物进行分离、纯化,得到8个单体化合物。通过现代波谱分析(1D NMR和MS等)和物理常数对照等方法对其进行结构鉴定,均为环二肽类物质,依次为:环(羟脯-苯丙)二肽(1)、环(脯-酪)二肽(2)、环(苯丙-甘)二肽(3)、环(苯丙-丙)二肽(4)、环(丙-酪)二肽(5)、环(亮-甘)二肽(6)、环(甘-缬)二肽(7)、环(丙-缬)二肽(8)。所有化合物均首次从该细菌中分离得到。更多还原

【Abstract】 Eight compounds 1-8 were obtained from the fermentation broth and mycelium of B-2 through modern methods for isolation and purification in order to research secondary metabolites from coral-derived endophytic bacteria Pelomonas puraquae sp. nov( B-2). Their structures were analyzed by1 H and13C NMR,MS and physical methods. The results indicated that they were composed of 8 compounds including cyclo( Hyp-Phe)( 1),cyclo( Pro-Tyr)( 2),cyclo( Phe-Gly)( 3),cyclo( Phe-Ala)( 4),cyclo( Ala-Tyr)( 5),cyclo( Leu-Gly)( 6),cyclo( Gly-Val)( 7) and cyclo( Ala-Val)( 8). They were all cyclo-dipeptides and first acquired from the coral-derived endophytic bacteria Pelomonas puraquae sp. nov( B-2).更多还原