【摘要】 目的分析河北省正在参加抗艾滋病毒治疗的通过性接触感染HIV者耐药性。方法采集辖区内正在接受抗艾滋病毒治疗的性接触感染HIV者的血浆,进行HIV基因型检测,分析基因突变。结果研究发现231例患者中有68例患者发生了基因突变,对抗艾滋病毒药物产生了不同程度的耐药性,耐药发生率为29.44%(68/231)。逆转录酶抑制剂的耐药发生率(29.00%,67/231)远高于蛋白酶抑制剂的耐药发生率(0.87%,2/231)。结论抗病毒药物的诱导作用是导致耐药突变的主要原因,在治疗过程中适时进行耐药监测是必要的,可为制定最佳治疗方案提供数据。更多还原

【Abstract】 In this study,we investigated the prevalence of HIV-1drug resistance among patients infected with HIV through sex behaviour who were receiving highly active anti-retroviral therapy(HAART)in Hebei Province.Plasma samples were collected from patients who were infected with HIV through sex behaviour.Then the detection of HIV-1genotype was implemented,and HIV drug-resistance mutations were analyzed.Results indicated that 68 of 231patients,infected with HIV-1by sex transmission,occurred drug-resistance mutation.The rate of the drug resistance was 29.44%(68/231).The rate of resistance to RTs(29.00%,67/231)was much higher than that of PIs(0.87%,2/231).Therefore,the main causation which resulted in therapic failure was drug-induced mutation.The detection of HIV drug resistance throughout HAART was useful so that we could make the better plan of highly active anti-retroviral therapy(HAART).更多还原