【摘要】 目的总结自噬及其在胃癌中的研究进展。方法检索并筛选近年来国内外发表的有关自噬与胃癌关系的文献并分别对自噬的特点、分子标志、调控因素及其在胃癌中的意义和作用进行综述。结果自噬既可促进细胞的死亡,也可延长肿瘤形成中癌细胞的存活。调控自噬的药物(包括中药)在肿瘤治疗中具有广阔的应用前景,但基于自噬调控的抗肿瘤治疗效果仍取决于细胞内自噬的实际水平。结论目前对胃癌自噬现象的了解仍然知之甚少,阐明自噬现象的分子机理并通过合理调控自噬来杀伤癌细胞仍然需要更为深入的实验研究。更多还原

【Abstract】 Objective To summarize the autophagy and its research progress in gastric cancer. Method In combination with available literatures published in recent years involving the relationship between autophagy and gastric cancer, the characteristics of autophagy, molecular marker, control factors, and the significance and role in gastric cancer were reviewed. Results Autophagy not only promotes cell death, but also can prolong the survival of cancer cells during the tumor formation. Reagents(including traditional Chinese medicine) regulating autophagy have broad prospect of application in cancer therapy, but anti-tumor therapeutic effect based on the regulation of autophagy depends on the actual level of intracellular autophagy. Conclusion The autophagy in the gastric cancer is still poorly understood, and to clarify the molecular mechanism of autophagy and kill cancer cells by reasonable regulation of autophagy still needs more further in-depth studies.更多还原