【摘要】 以5-溴水杨酸为原料,将其与水合肼反应生成了5-溴水杨酰肼,再将硫氰酸钾与5-溴水杨酰肼反应合成了5-溴水杨酰基氨基硫脲,后者与溴代乙酸乙酯反应生成了终产物N’-(2-羟基-5-溴苯甲酰胺基)-2-亚胺基-4-噻唑烷酮.对化合物进行了熔点、IR、元素分析、1H NMR、13C NMR表征,并测试了其对生物体的抗炎活性和抗菌活性.结果表明:N’-(2-羟基-5-溴苯甲酰胺基)-2-亚胺基-4-噻唑烷酮具有较好的抗炎、抗菌活性.更多还原

【Abstract】 5-bromo- salicylicacid was used to synthesize 5-bromo-methyl salicylate,which further reacted with hydrazine hydrate to obtain 5-bromosalicylaldehyde hydrazide. The 5-bromosalicylaldehyde hydrazine then reacted with potassium thiocyanate to form 5-bromosalicylaldehydethiosemicarbazides, which finally reacted with ethyl bromoacetate proceededcatalytic to afford N’-( 2-hydroxy-5-bromobenzoylamino)-2-imino-4-thiazolidinone. The structure of the final compound was characterized by IR,element analysis,1H NMR,and13 C NMR. The compound also showed good antiinflammatory and antibacterial activity.更多还原