【摘要】 目的:观察糖尿病视网膜病变(DR)合并抑郁状态患者的代谢、炎症指标变化及临床意义。方法:选取处于背景期的DR患者184例,分为单纯DR者(DR组)100例和合并抑郁状态者(DR+抑郁组)84例;检测两组患者代谢和炎症指标的变化。结果:DR+抑郁组患者的病程、糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、空腹胰岛素(Fins)、餐后2 h胰岛素(2 h Ins)及胰岛素抵抗指数(HOMA-IR)均高于单纯DR组(P<0.05),高敏C反应蛋白(hs C-RP)、IL-6、TNF-α和血浆皮质醇(COR)均低于单纯DR组(P<0.05)。结论:DR合并抑郁状态的患者糖尿病程度和炎症指标均高于单纯的DR患者。更多还原

【Abstract】 Objective: To observe changes of metabolism and inflammatory markers in diabetic retinopathy patients with depression and to explore their clinical significance. Methods: A total of 184 DR patients( background period) were divided into non-depression group( DR,n = 100) and depression group( DR + depression,n = 84). The changes of metabolism and inflammatory markers of the two groups were tested. Results:( 1) The diabetes course,Hb A1 c,FPG,2h PG,FIns,2 h Ins and HOMA- IR were higher in DR + depression group than in DR group( P < 0. 05);( 2) Compared with DR group,the levels of hs C- RP,IL- 6,TNF- α and COR in DR + depression group increased more obviously. Conclusions: The severity of diabetes and inflammatory markers in the diabetic retinopathy patients with depression are higher than those of only DR patients.更多还原