【摘要】 目的观察血管内皮生长因子(Vascular endothelial growth factor,VEGF)与整合素连接激酶(Integrin-linked kinase,ILK)在涎腺腺样囊性癌(Salivary adenoid cystic carcinoma,SACC)中的定位及表达,探讨VEGF与ILK在SACC中的作用,揭示SACC的发病机制.方法对30例SACC存档蜡块行免疫组化分析,观察VEGF与ILK在SACC中的表达分布情况.利用SPSS 13.0统计软件分析VEGF与ILK的差异性及相关性.结果在SACC中,VEGF阳性率为83.33%,ILK阳性率为76.67%;VEGF实验组与对照组比较,P<0.05,ILK实验组与对照组比较,P<0.05;VEGF与ILK在SACC中的表达存在正相关,r=0.388.结论在SACC的发生发展过程中,血管生成是其发生的重要步骤,血管的生长速率是其侵袭和转移的条件.VEGF与ILK在血管的生成过程中起着重要的作用,VEGF与ILK在SACC中的表达存在正性相关,它们共同作用于SACC的血管生成,影响SACC血管生长的速率.更多还原

【Abstract】 Objective To explore the expression of VEGF and ILK in SACC by IHC,to analyze the roles of VEGF and ILK and their correlation in SACC,and to reveal the pathogenesis of SACC. Method IHC was used to determine the expression of VEGF and ILK in 30 cases of SACC. The correlation of VEGF and ILK was statistically analyzed by SPSS. Results The positive rate of VEGF was 83. 33%,the positive rate of ILK was76. 67%. Differences between the experimental group of VEGF and the control group were significant( P < 0.05),and differences between the experimental group of ILK and the control group were significant( P < 0. 05).The expression of VEGF was positively correlated with ILK expression in SACC,r = 0. 388. Conclusion VEGF and ILK play a role in promoting the growth of SACC and tumor angiogenesis. In the development of SACC,angiogenesis is an important step,and vascular growth rate is the condition of invasion and metastasis. The expression of VEGF and ILK in SACC shows a positive correlation. They collaborate on angiogenesis and growth rate of blood vessel.更多还原