【摘要】 维生素D在人体钙磷代谢和骨质钙化中有着重要作用,同时,其对非钙磷代谢的一类其他疾病亦有密切关系。其中,维生素D缺乏与动脉粥样硬化关系日益受到国际上的重视。临床资料显示动脉粥样硬化患者普遍存在维生素D水平低下,越来越多的研究开始关注维生素D和维生素D受体与动脉粥样硬化之间的关系。液相色谱串联质谱法(LC-MS/MS)测定血浆25-羟维生素D浓度不仅比常用的酶免法精确度高,而且可以同时检测维生素D2和维生素D3的浓度,为探讨维生素D与动脉硬化进展的关系和临床指导维生素D补充治疗提供有力依据。此文旨在对探讨维生素D水平与心血管疾病的关系以及维生素D参与动脉粥样硬化机制研究作一综述。更多还原

【Abstract】 Vitamin D not only plays a major role in the human body calcium and phosphorus metabolism and bone calcification, but also closely relates to non-calcium and phosphorus metabolism diseases. The relationship of vitamin D deficiency and atherosclerosis is an increasing attention in the international medical community. Atherosclerosis in patients with vitamin D deficiency is very common, more and more studies began to place emphasis on whether there is a relationship between vitamin D and vitamin D receptor and atherosclerosis. This review aimed to describe the relationship of vitamin D deficiency and cardiovascular disease and related mechanism of vitamin D to participate in atherosclerosis.更多还原