【摘要】 溃疡性结肠炎(UC)是一种主要累及结肠和直肠的特异性炎症性疾病,有慢性、复发性等特点,发病机制尚不清楚。近年来,普遍认为UC的发病与基因易感性,宿主的免疫系统失调,共生的肠道菌群紊乱,氧化应激以及炎症介质的参与等有关。目前,肠道微生物的研究已成为UC发病机制的研究热点。各种益生菌、致病菌的研究结果层出不穷,它们在UC的发病机制中起到的作用至今尚无定论。本文就UC发病机制中肠道菌群方面的研究进展做简要综述。更多还原

【Abstract】 Ulcerative colitis(UC) is one kind of inflammatory diseases, which usually involves colon and rectum. UC has two characteristic of chronic and recidivity. In recent years, there are several factors that may contribute to the pathogenesis of UC, such as deregulation of immune system or commensally bacteria oxidative stress and inflammatory mediators. Nowadays, the researches of intestinal macrobiotic become the hotspot in the pathogenesis of UC. A variety of results research in probiotics and pathogen emerge in an endless stream. The role of these pathogenesis in UC is inconclusive. This review focused on the research progress in intestinal macrobiotic of UC.更多还原