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卵巢组织冷冻移植在肿瘤生殖学中的应用前景及存在问题

The application prospect in oncofertility and existing problems of ovarian tissue cryopreservation and transplantation

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【作者】 程洪艳昌晓红叶雪马瑞琼崔恒

【Author】 Cheng Hongyan;Chang Xiaohong;Ye Xue;Ma Ruiqiong;Cui Heng;Gynecology Oncology Center of Peking University People’s Hospital;

【机构】 北京大学人民医院妇科肿瘤中心

【摘要】 随着年轻肿瘤患者发病率和治愈率的提高,患者保存生殖能力的要求越来越迫切。卵巢组织冷冻移植作为女性生殖力保存的一种方法,具有生育力储备大、不受生理周期影响、适用于青春期前的年轻女性患者以及无法进行促排卵治疗的肿瘤患者等优于卵子冷冻和胚胎冷冻的独特优势,在肿瘤生殖学中具有重要的应用前景。但是,目前卵巢冷冻移植在技术和应用上还存在一些客观问题,本文综述了卵巢组织冷冻移中的冷冻复苏、存活检测、肿瘤残留检测、体外培养诱导卵泡发育、体内移植及受精发育等众多技术环节,论述了每一环节的具体技术方法、进展以及影响成败的关键因素和存在的问题。本文为广大医务和科研工作者全面了解卵巢组织冷冻移植在肿瘤生殖学中的应用和进展提供了理论参考。

【Abstract】 With the increasing of the incidence rate and cure rate in younger patients,the requirement for saving the reproductive ability of patients has become more and more urgent.Ovarian tissue cryopreservation and transplantation as a method of female fertility preservation,is superior to egg freezing and embryo freezing because of the unique advantages of high fertility reserves,not being affected by physiological cycles and being suitable for the prepubescent female patients and cancer patients can’t be promoted ovulation.Ovarian tissue cryopreservation and transplantation has important application prospects in oncofertility.While,there are some objective problems in the technology and application of ovarian tissue cryopreservation and transplantation at present.In this paper we summarized the technology in the process of ovarian tissue cryopreservation and transplantation such as cryopreservation and recovery,surviving detection,tumor residues detection,in vitro cultivation of follicular,in vivo transplantation,fertilization and embryo development.Progress and detailed methods,key factors affecting the success or failure and the existing problems in the process were discussed.This paper provided theoretical reference for the majority of medical and scientific research workers to have a comprehensive understanding of the application and progress of ovarian tissue cryopreservation and transplantation in oncofertility.

  • 【文献出处】 中华临床医师杂志(电子版) ,Chinese Journal of Clinicians(Electronic Edition) , 编辑部邮箱 ,2015年01期
  • 【分类号】R714.8
  • 【被引频次】6
  • 【下载频次】437
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