【摘要】 目的分析结肠癌CapeOX(奥沙利铂+卡培他滨)方案新辅助化疗的疗效、不良反应。方法从无锡市第二人民医院中筛选2010年1月至2012年12月确诊的52例晚期结肠癌患者,随机均分为两组。试验组采用奥沙利铂+卡培他滨(CapeOX),对照组采用奥沙利铂+氟尿嘧啶(mFOLFOX)。观察两组的疗效和毒副作用。结果两组患者各完成3个疗程的化疗后,试验组客观有效率达57.69%,优于对照组的23.07%,且差异具有统计学意义(P<0.05);试验组患者出现白细胞减少及肝功能异常等不良反应少于对照组,差异具有统计学意义(P<0.05)。结论 CapeOX方案新辅助化疗用于晚期结肠癌的疗效好,不良反应轻。更多还原

【Abstract】 Objective To investigate the clinical efficacy and adverse reactions during neoadjuvant chemotherapy using oxaliplatin and capecitabine in the treatment of advanced colon cancer patients.Methods From January 2010 to December 2012,52 advanced colon cancer patients in WUxi No.2 hospital were selected and divided into 2 group at random.The experimental group was given the combination therapy of oxaliplatin and capecitabine,while the control group was treated with oxaliplatin and 5-FU.Results The objective response rate after 3 course of treatment in the experimental group was 57.69%,which was better than 23.07% in the control group,and the difference was statistically significant( P < 0.05); the occurrence of leucopenia and liver function abnormality in the experimental group was statistically decreased compared with that of the control group,and the difference was statistically significant( P < 0.05).Conclusions The combination application of oxaliplatin and capecitabine has better therapeutic effect and fewer adverse reactions for treating advanced colon cancer.更多还原