【摘要】 目的分析浸润性乳腺癌不同分子亚型中p53与表皮生长因子受体(EGFR)的表达情况及其相关性。方法回顾性分析山东省肿瘤医院2012年1月至2013年8月264例可手术乳腺癌患者的临床及病理资料,分析分子亚型与临床病理特征的相关性及不同分子亚型中p53与EGFR表达的相关性。结果乳腺癌分子亚型与发病年龄、初潮年龄无统计学差异(均P>0.05)。分子亚型与是否绝经、肿瘤直径、淋巴结转移、病理分期、细胞角蛋白5/6(CK5/6)、p53及EGFR表达状况具有统计学差异(均P<0.05)。Luminal型乳腺癌患者T1期所占比例多于non-Luminal型乳腺癌患者(P<0.05)。p53与EGFR总体表达呈正相关(r=0.226,P<0.05),进一步分层分析显示各分子亚型中只有三阴性乳腺癌(TNBC)中p53与EGFR表达呈正相关(r=0.319,P<0.05),其他亚型中p53与EGFR表达无相关性(均P>0.05)。结论 p53与EGFR在TNBC中表达呈正相关,探讨二者的表达有助于进一步了解TNBC的分子生物学特征,并为TNBC的治疗提供新的思路。更多还原

【Abstract】 Objective To investigate the correlation between p53 and EGFR overexpression in distinct molecular subtypes of invasive breast cancer. Methods The clinicopathology data of 264 operable breast cancer patients from January 2012 to August 2013 were retrospectively analyzed,and the correlation of p53 and epidermal growth factor receptor( EGFR) expression in distinct molecular subtypes was investigated. Results No statistically significant differences were found among distinct molecular subtypes regarding age at diagnosis and age at menarche by using chi-square test( all P > 0. 05). Statistically significant differences were found among distinct molecular subtypes regarding menopause status,tumor size,lymph node status,pathological stage,Cytokeratin 5 /6( CK5 /6),p53 and EGFR( all P < 0. 05). There were more patients with T1 stage in Luminal subtype than that of in non-luminal subtype( P < 0. 05). p53 expression had a positive correlation with EGFR expression in invasive breast cancer( r = 0. 226,P < 0. 05). There was a significant positive correction between p53 and EGFR in triple-negative breast cancer( TNBC) by stratification analysis( r = 0. 319,P < 0. 05),not in other subtypes( all P > 0. 05). Conclusions There was a positive correlation between p53 and EGFR in TNBC.P53 and EGFR in TNBC may help us to comprehensively recognize the molecular biological characteristics of TNBC,and may offer us a new idea to TNBC treatment.更多还原