【摘要】 目的 探讨2型糖尿病(T2DM)患者血清微量元素含量的变化,及其与部分生化指标、T2DM发生发展的相关性。方法 检测2012年6月至2014年6月入住上海市徐汇区中心医院内分泌科的89例T2DM(T2DM组)患者和97例非T2DM(对照组,一般资料与T2DM组比较无差异)患者的空腹血糖(FBG)、餐后2h血糖(2hPBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、C肽等生化指标。采用电感耦合等离子体质谱(ICP-MS)技术检测铁(Fe)、锌(Zn)、硒(Se)3种微量元素含量,分析微量元素与生化指标及T2DM的关系。结果 与对照组比较,T2DM组血清Zn、Se含量均显著降低(P<0.05);与HbA1c<7.0%者比较,T2DM组中HbA1e≥7.0%者血清Fe、Zn、Se含量显著降低(P<0.05);Pearson相关性分析显示,T2DM患者血清Fe与Zn之间和Fe与Se之间分别呈正相关,Zn与Se之间亦呈正相关(r=0.668、0.725、0.754;P<0.05);Fe、Zn、Se与HbA1c、FBG、2hPG、FINS及C肽均具有良好的相关性;多因素logistic回归分析显示,Zn、Se是T2DM患者的保护因素(β=-1.302,-1.578;P<0.05)。结论 T2DM患者微量元素含量普遍较低,且与糖代谢密切相关,维持体内微量元素的平衡,对防止或延缓T2DM发病具有积极的意义。更多还原

【Abstract】 Objective To explore the changes in serum trace elements and its correlation with biochemical indicators and development of type 2 diabetes mellitus(T2DM) in patients with T2 DM.Methods A total of 89 patients with confirmed T2 DM admitted in the Endocrinology Department,Xuhui District Central Hospital of Shanghai from June 2012 to June 2014 were enrolled in this study.Another 97non-T2 DM patients(having no significant differences in age,sex,body mass index,and waist-hip ratio with the T2 DM group) in our hospital at the same duration were recruited as control group.Fasting blood glucose(FBG),2-hour postprandial glucose(2hPBG),glycosylated hemoglobin A1c(HbAlc),fasting insulin(FINS),and peptide C were measured.Inductively coupled plasma mass spectrometry(ICP-MS) was used to detect the serum levels of trace elements,Fe,Zn and Se.The correlation of serum trace elements with biochemical indicators and T2 DM was analyzed.Results Serum levels of Fe,Zn and Se were significantly lower in T2 DM group than in control group(P < 0.05),and also remarkably reduced in the T2 DM patients with HbA1 c ≥7.0%than in those with HbAlc < 7.0%(P < 0.05).Pearson correlation analysis showed that there was positive correlation between Fe and Zn,Fe and Se,and Zn and Se,respectively(r = 0.668,0.725,0.754,P<0.05).Serum levels of Fe,Zn and Se were all highly correlated with HbAlc,FBG,2hPBG,FINS and peptide C.Multivariate logistic regression analysis showed that Zn and Se were the protective factors for T2DM(β =-1.302,-1.578;P < 0.05).Conclusion The serum levels of trace elements are generally low in T2 DM patients,and the levels are closely related to the glycometabolism.So maintaining the balance of trace elements is of positive significance in the prevention or onset delay of T2 DM.更多还原