节点文献
抗生素对细胞内致病原的药动学及药效学
Intracellular pharmacokinetics and pharmacodynamics of antibiotics
【摘要】 本文对细胞内抗生素的药动学和药效学参数进行了综述。优化抗生素治疗,不仅应考虑其在细胞外的抗菌活性,而且应综合考虑宿主细胞对抗生素药动学及药效学的影响。
【Abstract】 This article summarized the pharmacokinetic-pharmacodynamic parameters that are important when considering the intracellular activity of antibiotics. Optimizing antibiotic treatment, not only its extracellular antibacterial activity but also the effect of host cell on antibiotic pharmacokinetics and pharmacodynamics should be considered.
【关键词】 抗生素;
细胞内;
药动学;
药效学;
【Key words】 Antibiotics; Intracellular; Pharmacokinetics; Pharmacodynamics;
【Key words】 Antibiotics; Intracellular; Pharmacokinetics; Pharmacodynamics;
【基金】 国家科技部十二五重大专项滚动课题项目(No.2012ZX09303004-002);解放军总医院临床扶持基金(No.2014-TS-YS-2007)
- 【文献出处】 中国抗生素杂志 ,Chinese Journal of Antibiotics , 编辑部邮箱 ,2015年06期
- 【分类号】R96
- 【被引频次】6
- 【下载频次】271