【摘要】 牙周病是以牙周支持组织的炎症和破坏为特征的感染性疾病。牙周病基础治疗是通过去除牙菌斑以达到控制炎症的目的。但是,牙周治疗的最终目的在于修复并重建牙周组织的结构和功能,包括牙槽骨、牙周韧带、牙骨质等牙周支持组织的再生。组织工程技术的出现为牙周组织再生治疗提供了新的思路和方法,其中具有增殖分化潜能的种子细胞是目前研究热点之一。间充质干细胞属于成体干细胞,是来源于发育早期中胚层的具有高度自我更新能力和多向分化潜能的干细胞,是理想的种子细胞之一。牙源性间充质干细胞具有再生和分化潜力好、免疫原性低的特点,因而成为牙周组织再生的种子细胞。本文将针对目前研究发现的牙源性间充质干细胞的特性及在牙周组织再生中的应用作一综述。更多还原

【Abstract】 Periodontitis is a chronic infective disease, which characterized as inflammation and destruction of the supporting tissues of the teeth. Traditional treatment strategies focus on the removal of dental plaque and the long-term control of dental plaque accumulation. However, the ultimate object of periodontal therapy is to restore the structure and function of the periodontium, which means regeneration of the supporting tissues, including alveolar bone, periodontal ligament and cementum,over a previously diseased root surface. The development of tissue engineering provides a new thought to periodontal regeneration therapy. Mesemchymal stem cells, with highly proliferation and differentiation potential, are ideal adult stem cells developed from mesoderm. With the identification of mesenchymal stem cells in oral cavity, tissue engineering using mesenchymal stem cells has become a most interesting therapeutic option. The aim of this article was to describe the main sources of dental-derived mesenchymal stem cells and their potential in regenerative therapy.更多还原