节点文献
IL-33、ST2在慢性阻塞性肺疾病急性加重患者中的表达及意义
IL-33 and ST2 levels in serum and sputum in patients with acute exacerbation of chronic obstructive pulmonary disease
【摘要】 目的探讨IL-33、ST2在慢性阻塞性肺疾病(COPD)急性加重患者中的表达及其意义。方法选取2010年12月至2012年12月COPD急性加重患者30例为病例组,匹配同期健康体检者30例为对照组。使用ELISA法测定治疗前后血清、痰液中IL-33和ST2的表达,并收集患者住院期间肺功能、血气分析、血常规、C反应蛋白(CRP)等临床相关资料进行分析。结果病例组治疗前血清ST2水平显著高于对照组,差异有统计学意义(P<0.05);而痰液ST2、痰液IL-33以及血清IL-33在两组比较中均无统计学差异(均P>0.05)。治疗后病例组血清ST2水平显著低于治疗前(P<0.05),与对照组比较无统计学差异(P>0.05)。病例组治疗后IC%显著性升高(P<0.05),同时CRP显著降低P<0.05)。相关性分析发现血清ST2与IC%、FEV1%呈显著负相关(均P<0.05),与CRP、二氧化碳分压(PCO2)、氧分压(PO2)、乳酸(LA)及血白细胞(WBC)未发现有明显相关性(均P>0.05)。结论血清ST2水平在COPD急性加重期明显增高,治疗缓解后显著降低,并可恢复正常。血清ST2可作为判断COPD病情变化的一项血清生物标志物。
【Abstract】 Objective To investigate serum and sputum levels of IL-33 and ST2 in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and their clinical significance.Methods Thirty patients with AECOPD(case group) and 30 age-matched healthy subjects(control group) were recruited in this study.The serum and sputum IL-33,ST2 levels were measured by ELISA in 30 AECOPD before and after treatment,and 30 healthy age-matched subjects,Resulte The serum levels of ST2 in AECOPD before treatment were significantly higher than those in normal controls(P<0.05) but the serum levels of IL-33 and the sputum levels of IL-33 and ST2 had no difference with those in normal controls(P >0.05).There were no statistical differences in the serum levels of ST2 between AECOPD patients after treatment and normal controls(P >0.05);and there were significant differences in AECOPD patients before and after treatment(P<0.05).The serum levels of ST2 were negatively correlated with FEV1%and IC%in patients(P<0.05).Conclusion Serum levels of ST2 might be used as a marker to evaluate the condition of AECOPD patients.
- 【文献出处】 浙江医学 ,Zhejiang Medical Journal , 编辑部邮箱 ,2015年15期
- 【分类号】R563.9
- 【被引频次】5