【摘要】 目的探讨IL-33、ST2在慢性阻塞性肺疾病（COPD）急性加重患者中的表达及其意义。方法选取2010年12月至2012年12月COPD急性加重患者30例为病例组,匹配同期健康体检者30例为对照组。使用ELISA法测定治疗前后血清、痰液中IL-33和ST2的表达,并收集患者住院期间肺功能、血气分析、血常规、C反应蛋白（CRP）等临床相关资料进行分析。结果病例组治疗前血清ST2水平显著高于对照组,差异有统计学意义（P<0.05）;而痰液ST2、痰液IL-33以及血清IL-33在两组比较中均无统计学差异（均P>0.05）。治疗后病例组血清ST2水平显著低于治疗前（P<0.05）,与对照组比较无统计学差异（P>0.05）。病例组治疗后IC%显著性升高（P<0.05）,同时CRP显著降低P<0.05)。相关性分析发现血清ST2与IC%、FEV₁%呈显著负相关（均P<0.05）,与CRP、二氧化碳分压（PCO₂）、氧分压（PO₂）、乳酸（LA）及血白细胞（WBC）未发现有明显相关性（均P>0.05）。结论血清ST2水平在COPD急性加重期明显增高,治疗缓解后显著降低,并可恢复正常。血清ST2可作为判断COPD病情变化的一项血清生物标志物。更多还原

【Abstract】 Objective To investigate serum and sputum levels of IL-33 and ST2 in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD） and their clinical significance.Methods Thirty patients with AECOPD（case group） and 30 age-matched healthy subjects（control group） were recruited in this study.The serum and sputum IL-33,ST2 levels were measured by ELISA in 30 AECOPD before and after treatment,and 30 healthy age-matched subjects,Resulte The serum levels of ST2 in AECOPD before treatment were significantly higher than those in normal controls（P<0.05） but the serum levels of IL-33 and the sputum levels of IL-33 and ST2 had no difference with those in normal controls（P >0.05）.There were no statistical differences in the serum levels of ST2 between AECOPD patients after treatment and normal controls（P >0.05）;and there were significant differences in AECOPD patients before and after treatment（P<0.05）.The serum levels of ST2 were negatively correlated with FEV₁%and IC%in patients（P<0.05）.Conclusion Serum levels of ST2 might be used as a marker to evaluate the condition of AECOPD patients.更多还原