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IL-33、ST2在慢性阻塞性肺疾病急性加重患者中的表达及意义

IL-33 and ST2 levels in serum and sputum in patients with acute exacerbation of chronic obstructive pulmonary disease

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【作者】 袁志张根生陈志勇廖凯兴钟成李静杰冯马龙王群沈华浩

【Author】 YUAN Zhi;ZHANG Gensheng;CHEN Zhiyong;Department of Respiratory,Fenghua People’s Hospital;

【机构】 奉化市人民医院呼吸内科浙江大学医学院附属第二医院重症医学科奉化市人民医院检验科浙江大学医学院附属第二医院呼吸和危重症医学科

【摘要】 目的探讨IL-33、ST2在慢性阻塞性肺疾病(COPD)急性加重患者中的表达及其意义。方法选取2010年12月至2012年12月COPD急性加重患者30例为病例组,匹配同期健康体检者30例为对照组。使用ELISA法测定治疗前后血清、痰液中IL-33和ST2的表达,并收集患者住院期间肺功能、血气分析、血常规、C反应蛋白(CRP)等临床相关资料进行分析。结果病例组治疗前血清ST2水平显著高于对照组,差异有统计学意义(P<0.05);而痰液ST2、痰液IL-33以及血清IL-33在两组比较中均无统计学差异(均P>0.05)。治疗后病例组血清ST2水平显著低于治疗前(P<0.05),与对照组比较无统计学差异(P>0.05)。病例组治疗后IC%显著性升高(P<0.05),同时CRP显著降低P<0.05)。相关性分析发现血清ST2与IC%、FEV1%呈显著负相关(均P<0.05),与CRP、二氧化碳分压(PCO2)、氧分压(PO2)、乳酸(LA)及血白细胞(WBC)未发现有明显相关性(均P>0.05)。结论血清ST2水平在COPD急性加重期明显增高,治疗缓解后显著降低,并可恢复正常。血清ST2可作为判断COPD病情变化的一项血清生物标志物。

【Abstract】 Objective To investigate serum and sputum levels of IL-33 and ST2 in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and their clinical significance.Methods Thirty patients with AECOPD(case group) and 30 age-matched healthy subjects(control group) were recruited in this study.The serum and sputum IL-33,ST2 levels were measured by ELISA in 30 AECOPD before and after treatment,and 30 healthy age-matched subjects,Resulte The serum levels of ST2 in AECOPD before treatment were significantly higher than those in normal controls(P<0.05) but the serum levels of IL-33 and the sputum levels of IL-33 and ST2 had no difference with those in normal controls(P >0.05).There were no statistical differences in the serum levels of ST2 between AECOPD patients after treatment and normal controls(P >0.05);and there were significant differences in AECOPD patients before and after treatment(P<0.05).The serum levels of ST2 were negatively correlated with FEV1%and IC%in patients(P<0.05).Conclusion Serum levels of ST2 might be used as a marker to evaluate the condition of AECOPD patients.

【关键词】 肺疾病慢性阻塞性IL-33ST2
【Key words】 Pulmonary diseaseChronic obstructiveIL-33ST2
【基金】 宁波市社会科技发展专项基金(2013C50037)
  • 【文献出处】 浙江医学 ,Zhejiang Medical Journal , 编辑部邮箱 ,2015年15期
  • 【分类号】R563.9
  • 【被引频次】5
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