【摘要】 目的总结与探讨中国大陆地区近10余年间病毒肝炎合并接合菌病的流行病学特点及诊疗情况。方法检索分析重庆维普、CNKI系列数据库、万方数据库、中国医师协会全文期刊库及Pubmed等数据库中2000年以来的中国大陆地区肝炎合并接合菌病的相关文献资料。结果共检索文献10篇,病例19例。患者的平均发病年龄为37.6岁,男女比例为18∶1,总死亡率为78.95%。其临床表现无特异性,诊断主要依赖于真菌学及组织病理学检查。治疗方法首选两性霉素B,联合手术治疗较之单独抗真菌药物疗效更好。结论近年来中国大陆地区肝炎合并接合菌病发病率呈上升趋势。对肝炎并高度怀疑接合菌感染的患者,宜尽早启动抗真菌治疗,及时联合病灶切除者疗效更佳。更多还原

【Abstract】 Objective To investigate the epidemiology and clinical characteristics of hepatitis complicated with zygomycosis in China’s mainland. Methods Literatures about hepatitis complicated with zygomycosis in China were collected from the electrical databases,such as CNKI,CJDF,VIP,Chinese physician full-text journals,and also Pubmed since 2000. Results 10 articles( 19 cases)were included in the study. Median age was 37. 6( range,20-62) years old,with a male predominance( M ∶ F = 18 ∶ 1). Without specific clinical and radiographic features,its diagnosis was mainly dependent on mycologic and / or histopathological examination.Amphotericin B was the first-line antifungal drug for hepatitis complicated with zygomycosis,and better efficacy could be got if combined with surgical treatment. Conclusions In recent years,there is an increasing trend in the prevalence of hepatitis complicated with zygomycosis in China’s mainland. For highly suspected hepatitis complicated with zygomycosis,it’s necessary to initiate early antifungal therapy,and combined surgical treatment may improve the outcome.更多还原