【摘要】 刚地弓形虫棒状体蛋白2家族(ROP2 family)是由弓形虫棒状体分泌的一类蛋白质,对弓形虫侵入宿主细胞及发挥细胞毒力起重要作用。ROP2家族成员包括ROP2、ROP4、ROP5、ROP8、ROP13、ROP16、ROP17和ROP18。近年来的研究发现,ROP2家族成员作为疫苗候选分子,可诱导宿主产生保护性免疫。本文综述了ROP2家族主要成员作为DNA疫苗或蛋白疫苗的研究进展。更多还原

【Abstract】 Toxoplasma gondii rhoptry protein 2 family(ROP2 family), secreted by the rhoptry, plays an important role in T. gondii invasion of host cells and its virulence. The ROP2 family members include ROP2, ROP4,ROP5, ROP8, ROP13, ROP16, ROP17, and ROP18. Recent studies have found that these members are potential vaccine candidates against toxoplasmosis, and can induce the protective immunity of the host. This paper reviews the research advance on the ROP2 family members as DNA or protein vaccines against toxoplasmosis.更多还原