【摘要】 芍药苷(paeoniflorin,PF)是芍药的主要有效成分,具有多种药理作用。该文从调节自噬,调节免疫,抑制炎症因子产生,调节钙离子、钾离子通道,阻断酸敏感离子通道,调节有丝分裂原激活蛋白激酶(mitogenactivated protein kinase,MAPK)、磷脂酰肌醇-3-羟激酶(phosphatidyl Inositol 3-kinase,PI3K)/蛋白激酶B(protein kinase B,Akt)、核因子E2相关因子2(nuclear factor erythroid-2-related factor 2,Nrf2)/抗氧化反应元件(antioxidant responsive element,ARE)信号转导通路,对抗神经毒性,激活2型大麻素受体,抗氧化应激,抑制神经细胞凋亡等方面综述芍药苷的神经保护作用。更多还原

【Abstract】 Paeoniflorin(paeoniflorin,PF) is one of the main effective components of herbaceouspeony with many kinds of pharmacologic effect. This article reviews the neuroprotective effect of paeoniflorin in the following several aspects:regulate autophagy,regulate immunity,inhibit inflammatory cytokines,adjust Ca2+,K+ channels,block acid-sensing ion channels,adjust MAPK、PI3 K/Akt、Nrf2/ARE signal pathways,reduce neurotoxicity,activate cannabinoid receptor 2,antioxidant stress,inhibit neuron cells apoptosis.更多还原