Objectives To construct vectors for eukaryotic expression of genes of the hepatitis C virus(HCV)that encode multiple epitopes,to establish stable cell lines by transfecting those vectors into SP2/0cells,and to attempt to evaluate the immune reaction induced by a vaccine in a mouse xenograft tumor model. Methods The gene M2,which includes 10 epitopes of CTL,was synthesized,and the gene M1M2 was synthesized by combining M2 with M1,which includes various B cell and T cell epitopes.The genes M2 and M1M2 were ob...
【基金】
四川大学实验技术立项资助课题(No.0083304116008)
【更新日期】
2015-06-17
【分类号】
R392;R373.2
【正文快照】
丙型肝炎病毒(hepatitis C virus,HCV)感染是慢性肝病的最主要病因之一。我国是丙肝的高发区,一般人群感染率平均为3.2%[1-3]。HCV感染较其他类型肝炎病毒感染的危害性大,感染早期难以产生有效的抗病毒免疫,肝炎易慢性化,与肝硬化、肝癌的发生关系密切。HCV感染的标准治疗手段?
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