Objective To analyze the secondary structure and dominant B cell and T cell epitopes of the outer membrane protein PorB of Neisseria gonorrhoeae. Methods The transmembrane domain of the full-length amino acid sequence of PorB was analyzed using the online tool TMHMM,its secondary protein structure was predicted with the help of the GOR4 and SOPMA tools on the EXPASY server,and the flexibility,hydrophilicity,surface accessibility,and antigenicity of the PorB protein were analyzed with the Karplus-Schulz meth...
【基金】
云南省科技厅科学研究基金项目(No.2009ZC123M)
【更新日期】
2015-06-09
【分类号】
R378.16
【正文快照】
***II software.Conclusion T and B cell epitopes of PorB protein were analyzed by means of a bioinformatics approach.Tcell epitopes are possibly present at amino acids 18-32,126-142,and 186-200and B cell epitopes are possibly presentat amino acids 165-175,