【摘要】 由于眼部生理结构复杂和诸多屏障的存在,许多药物对眼部疾病的治疗作用甚微。为改善眼用药物的疗效,可使用胶体(纳米混悬剂、脂质体、微乳/纳米乳、脂肪乳和纳米粒)、原位凝胶及固体制剂等给药系统提高药物在眼部的滞留时间、减少药物的全身吸收。本文综述了上述给药系统的研究进展,也指出了一些阻碍其发展的障碍。更多还原

【Abstract】 Due to the complexity of ocular physiological structure and the existence of numerous barriers,many drugs have little effect on the eye diseases.To improve the therapy efficacy of ophthalmic drugs,colloidal systems(including nanosuspensions,liposomes,micro-/nano- emulsions,fat emulsions and nanoparticles),in situ gel and solid preparation for ophthalmic delivery are adopted to prolong drug corneal retention and reduce the systemic absorption.This paper reviews the recent advances of above drug delivery systems,but also points out some obstacles.更多还原