【摘要】 经颅多普勒(TCD)作为一种非侵入性、廉价和安全简便的检查手段,在评估血流动力学及脑血管功能方面得到广泛的应用。血流动力学异常是老年个体认知功能下降或预测痴呆的重要标记物。脑的慢性低灌注可影响脑细胞功能,导致神经系统变性改变。TCD能在很大程度上评估脑血管功能对认知功能损害及脑老化的影响,对痴呆与正常老化的鉴别以及痴呆亚型如阿尔茨海默病(AD)和血管性痴呆(Va D)的鉴别也有重要价值。本文系统介绍TCD在血流动力学相关性认知功能障碍包括痴呆、轻度认知功能损害及老化中的应用。更多还原

【Abstract】 Transcranial Doppler(TCD) ultrasonography has been increasingly employed as a noninvasive,inexpensive,safe and portable technique for measuring hemodynamics or cerebrovascular function.Hemodynamic abnormalities may be critical markers of dementia and cognitive decline in elderly individuals.Chronic cerebral hypoperfusion could affect cellular health within the brain and the development of neurodegenerative pathologies.TCD methods have much to provide the assessment of functional cerebrovascular contributions to cognitive impairment in dementia and aging and may help in the differentiation of dementia from normal aging and between the subtypes such as Alzheimer’s disease(AD) and vascular dementia(VaD).This paper aimed to systematically review previous research assessing hemodynamics-related cognitive dysfunction including dementia,mild cognitive impairment(MCI),and aging by using TCD techniques.更多还原