【摘要】 [目的]分析既往血吸虫病疫区感染人群大肠癌发病风险,为制定大肠癌预防和控制策略提供依据。[方法]比较上海市松江区既往血吸虫病疫区与非疫区大肠癌发病情况;并对2012年220 175名筛查对象的筛查资料进行非条件Logistic回归分析。[结果 ]2002~2009年松江区大肠癌发病呈上升趋势;松江区既往血吸虫病疫区(车墩、洞泾、中山、佘山、泗泾、九亭、新桥)的大肠癌发病率高于其他非疫区(岳阳、泖港、小昆山、叶榭、方松、石湖荡、新浜、永丰);2005~2009年松江区大肠癌发病率高于与上海市其他非血吸虫病疫区区县。非条件性Logistic回归分析表明血吸虫感染与大肠癌发病相关(OR=6.048,95%CI:5.249~6.971,P<0.001)。[结论 ]既往血吸虫病疫区感染人群大肠癌发病风险增高。更多还原

【Abstract】 [Purpose] To investigate the risk of colorectal cancer in the population with past Schistosomiasis infection,and to provide evidences for the prevention and treatment of colorectal cancer.[Methods] The standardized incidence of colorectal cancer between the past Schistosomiasis epidemic and un-epidemic areas in Songjiang district,Shanghai compared and analyzed,and the data of 220 175 screening objects in 2012 was analyzed by Logistic regression. [Results] The incidence of colorectal cancer was increasing from 2002 to 2009 in Songjiang district. The incidence of colorectal cancer in past Schistosomiasis epidemic areas(Chedun,Dongjing,Zhongshan,Sheshan,Sijing,Jiuting,Xinqiao was higher than that in un-epidemic areas(Yueyang,Maogang,Xiaokunshan,Yexie,Fangsong,Shihudang,Xinbang,Yongfeng in Songjiang district. The incidence of colorectal cancer in Songjiang district was higher than that in past Schistosomiasis un-epidemic districts of Shanghai. The Logistic regression showed that the occurrence of colorectal cancer was related to the Schistosomiasis infection(OR=6.048,95%CI:5.249~6.971,P<0.001). [Conclusion]The risk of colorectal cancer increased in the population with past Schistosomiasis infection.更多还原