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Her-2表达在食管胃结合部腺癌中的作用研究进展
Progress of Her-2 Expression in Gastroesophageal Junction Adenocarcinomas
【摘要】 近几十年来,食管胃结合部腺癌的发病率正在逐年上升。Her-2表达与食管胃结合部腺癌预后的研究结果呈现争议,研究认为这是因为Her-2检测的局限性和组织标本的异质性而导致不同的结果。对于Her-2过表达的食管胃结合部腺癌,综合治疗包括新辅助放化疗、辅助放化疗、手术治疗及靶向治疗在临床疗效中的地位越来越突出,中医药治疗也在辅助治疗中起到重要作用。
【Abstract】 In recent decades,the incidence of gastroesophageal junction(GEJ)adenocarcinomas is increasing. The relationship between Her-2 expression and prognosis of GEJ adenocarcinomas shows controversy. It leads to different results because of Her-2 detection limitations and tissue heterogeneity. For GEJ adenocarcinomas with Her-2 overexpression,comprehensive therapy including neoadjuvant chemotherapy,adjuvant radiotherapy,surgery and targeted therapy is becoming more and more prominent in the clinic. Traditional Chinese medicine has played an important role in the adjuvant therapy.
【Key words】 gastroesophageal junction adenocarcinomas; human epidermal growth factor receptor 2; comprehensive therapy;
- 【文献出处】 中国肿瘤 ,China Cancer , 编辑部邮箱 ,2015年01期
- 【分类号】R735.1
- 【被引频次】6
- 【下载频次】238