【摘要】 目的:探讨胆囊肉瘤样癌的临床病理特点、诊断及鉴别诊断。方法:分析6例胆囊肉瘤样癌的临床特点、组织病理学及免疫组织化学特点,进行随访,并复习相关文献。结果:胆囊肉瘤样癌组织病理学上以梭形细胞为主,免疫组织化学提示上皮标记及间叶标记阳性。结论:胆囊肉瘤样癌可以通过组织病理学特点、免疫组织化学标记明确诊断。目前治疗手段以根治性切除为主,但是由于该恶性肿瘤发生率较低,仍需搜集相关病例并长期随访跟踪,找到更好的治疗方法,以提高患者的生存率或生存质量。更多还原

【Abstract】 Objective: To investigate the clinicopathological features, diagnosis, and differential diagnosis of gallbladder sarcomatoid carcinoma. Methods: The clinical manifestations and the microscopic and immunohistochemical characteristics of six patients with gallbladder sarcomatoid carcinoma were analyzed with a follow-up period. Related literature was reviewed. Results:Immunohistochemical markers of gallbladder sarcomatoid carcinoma with spindle cell morphology were epithelial and mesenchymal positivity. Conclusion: Gallbladder sarcomatoid carcinoma could be firmly diagnosed by microscopic morphology and immunohistochemistry. Radical resection is currently used to treat such patients. However, more cases with longer follow-up period are needed to discover better treatments and improve the survival of these patients.更多还原