【摘要】 细胞分裂周期蛋白CDC25磷酸酶与细胞周期依赖性蛋白的调控以及细胞增殖密切相关,且在许多肿瘤中过度表达,CDC25磷酸酶已经成为很有前景的癌症治疗靶标。许多结构多样的天然产物及合成小分子化合物被证实是特异性的CDC25磷酸酶和抗肿瘤先导化合物,本文对该领域的研究新进展进行综述。更多还原

【Abstract】 Cell division cycle( CDC) 25 protein phosphatases represent an attractive potential therapeutic antiproliferative target for small molecule intervention because of its essential roles in positively regulating cyclin dependent kinases( CDKs) and cell proliferation,as w ell as its overexpression frequently observed in many human tumors. Over the past few years,many natural and synthetic molecules w ith different structural features targeting CDC25 activity have been reported. These compounds provide a new starting point for further structural optimization,w hich may afford new discoveries of inhibitory agents against the CDC25 phosphatases. Hence,this review aims to provide an overview of recent developments on design of CDC25 phosphatase inhibitors since 2008.更多还原