【摘要】 目的:探讨脱氢表雄酮联合美洛昔康片对骨关节炎患者的疗效及实验室指标的影响。方法:104例骨关节炎患者按照随机数字表法分为试验组和对照组,各52例。对照组患者口服美洛昔康片,7.5 mg/次,bid;试验组患者在对照组基础上加服脱氢表雄酮,25 mg/次,qd。两组疗程均为4周。比较两组患者临床疗效和治疗前后视觉模拟评分法(VAS)评分、关节功能评分、血清促炎细胞因子白细胞介素(IL)-1β水平、肿瘤坏死因子(TNF)-α水平以及软骨厚度、滑膜厚度、关节腔积液积分变化。结果:试验组患者总有效率(86.54%)显著高于对照组(69.23%),差异有统计学意义(P<0.05);治疗后两组患者VAS评分较治疗前显著下降,关节功能评分较治疗前显著增加,差异有统计学意义(P<0.05),且试验组患者VAS评分显著低于对照组,关节功能评分显著高于对照组,差异有统计学意义(P<0.05);治疗后两组患者血清IL-1β和TNF-α水平较治疗前显著降低,差异有统计学意义(P<0.05),且试验组患者血清IL-1β和TNF-α水平显著低于对照组,差异有统计学意义(P<0.05);两组患者关节软骨厚度治疗前后比较差异无统计学意义(P>0.05),而滑膜厚度、关节腔积液积分治疗后较治疗前显著减少,差异有统计学意义(P<0.05),且试验组患者滑膜厚度、关节腔积液积分显著少于对照组,差异有统计学意义(P<0.05)。结论:脱氢表雄酮联合美洛昔康片对骨关节炎疗效显著,可明显减轻患者疼痛,并降低血清IL-1β和TNF-α水平。更多还原

【Abstract】 OBJECTIVE:To explore the effects of dehydroepiandrosterone(DHEA)combined with Meloxicam tablets on therapeutic efficacy of osteoarthritis and biochemical indicator. METHODS:104 patients with osteoarthritis were randomly divided into experimental group and control group with 52 cases in each group. Control group only received Meloxicam tablets,7.5 mg/time,bid;experimental group was additionally given DHEA,25 mg/time,qd,on the basis of control group. The treatment course of 2 groups was four weeks. The clinical efficacy,VAS score before and after treatment,joint function score,levels of IL-1 β and TNF-α,cartilage thickness,synovial thickness and score of liquid aggregation of joint cavity were compared between 2 groups. RESULTS:The total effective rate of experimental group(86.54%)was significantly higher than that of control group(69.23%),with statistical significance(P<0.05);compared with before treatment,VAS scores of 2 groups decreased significantly after treatment,while joint function scores increased significantly,with statistical significance(P<0.05). VAS score of experimental group was significantly lower than that of control group,while joint function score was significantly higher than control group,with statistical significance(P<0.05). After treatment,the serum levels of IL-1β and TNF-α in 2 groups significantly decreased,with statistical significance(P<0.05);those of experimental group were significantly lower than those of control group,with statistical significance(P<0.05);there was no statistical significance in the cartilage thickness between 2 groups before and after treatment(P>0.05). Compared with before treatment,the thickness of the synovial membrane and the score of liquid aggregation of joint cavity significantly decreased after treatment,with statistical significance(P<0.05);the thickness of synovial membrane and the score of liquid aggregation of joint cavity in experimental group were significantly lower than in control group,with statistical significance(P<0.05). CONCLUSIONS:DHEA combined with Meloxicam tablets is significant in the treatment of osteoarthritis,can significantly relief the pain and decrease the levels of serum IL-1β and TNF-α.更多还原