【摘要】 目的:研究罗格列酮(RH)对糖尿病模型兔体质量,空腹血糖(FPG)及游离脂肪酸(FFA)等的影响。方法:取18只兔随机均分为对照组、模型组、右旋糖酐组,后2组兔iv四氧嘧啶复制糖尿病模型,然后3组兔ig RH(0.5 mg/kg),其中右旋糖酐组兔给药同时iv右旋糖酐40葡萄糖注射液(5 ml/kg),每日1次,连续给药3周。检测给药前及给药后各组兔的体质量和血清中FPG、FFA、血管紧张素Ⅱ(AngⅡ)、NO水平。结果:与给药前比较,对照组兔给药后体质量增加,FFA、AngⅡ水平降低;模型组兔给药后FPG、FFA水平降低;右旋糖酐组兔给药后体质量降低,差异有统计学意义(P<0.01或P<0.05),其余指标差异无统计学意义(P>0.05)。其中,右旋糖酐组兔给药后FFA水平高于模型组,差异有统计学意义(P<0.01)。结论:罗格列酮可增加兔的体质量,其机制可能与降低FFA水平有关。更多还原

【Abstract】 OBJECTIVE:To study the effects of rosiglitazone(RH)on body weight,FPG,FFA and other indicators in diabetes model rabbit. METHODS:18 rabbits were evenly randomized into control group,model group and dextran group. The latter 2groups were given alloxan intravenously to induce diabetes model. 3 groups were given RH(0.5 mg/kg)intragastrically,and dextran group was additionally given dextran 40 glucose injection(5 ml/kg)intravenously,once a day,for consecutive 3 weeks. Body weight,serum level of FPG,FFA,Ang Ⅱ and NO were determined before and after medication. RESULTS:Compared with before medication,body weight of rabbits in control group were increased after medication,while the levels of FFA and AngⅡ were decreased;the levels of FPG and FFA were decreased in model group;body weight of rabbits were decreased in dextran group after medication,with statistical significance(P<0.01 or P<0.05);other indicators had no statistically significant difference(P>0.05). The level of FFA in dextran group was higher than in model group after medication,with statistical significance(P<0.01).CONCLUSIONS:Rosiglitazone can lead to weight gain by a mechanism which reduce the level of FFA.更多还原