【摘要】 目的:测定唐山市市售5种主要中药材粉剂三七、当归、川芎、首乌、大黄中铅(Pb)、镉(Cd)、汞(Hg)、砷(As)、铜(Cu)5种重金属的含量。方法:采用微波消解-电感耦合等离子体质谱法进行测定,并采用单因子指数法和内梅罗综合指数法对中药材粉剂样品中的重金属污染进行评价;采用《药用植物及制剂进出口绿色行业标准》的重金属限量值评价样品重金属污染状况。结果:在5种12个批次的中药材粉剂样品中,重金属超标样品2个,分别是三七-3、川芎-2,样品超标率为16.7%,超标重金属为Cd、Hg,超标率分别为16.7%、8.3%;单因子指数>1的样品有三七-3中的Cd和Hg,川芎-2中的Cd,综合指数分别为1.06、0.81,污染水平分别为轻污染和警戒线水平。结论:唐山市市售中药材粉剂中存在一定程度的重金属污染。因此,有必要对中药材中的重金属含量进行更加严格的控制。更多还原

【Abstract】 OBJECTIVE:To determine the contents of Pb,Cd,Hg,As and Cu in Panax notoginseng,Angelica sinensis,Ligusticum chuanxiong,Fallopia multiflora and Rheum palmatum commercially available in Tangshan. METHODS:Microwave digestion-inductively coupled plasma mass spectrometry(ICP-MS)and single factor index and Nemerow comprehensive index were used to evaluate the heavy metal pollution in TCM powder samples;and the heavy metal limiting values in Green Trade Standards of Importing & Exporting Medical Plants & Prescriptions were used to evaluate the pollution of heavy metal samples. RESULTS:In the samples in 12 batches of 5 TCM powders,there were 2 heavy metal exceeded samples(P. notoginseng-3 and L. chuanxiong-2),the exceeded rate was 16.7%,exceeded indexes were Cd and Hg with the exceeded rates of 16.7% and 8.3%,respectively;heavy metals with Single factor index greater than 1 were Hg and Cd in P. notoginseng-3,and Cd in L. chuanxiong-2 with the composite indexes of 1.06 and 0.81,and pollution levels were slightly polluted and reaching warning level,respectively. CONCLUSIONS:Certain heavy metal pollution is found in TCM powder commercially available in Tangshan. Therefore,it is necessary to carry out more strictly control over the heavy metal content in Chinese herbal medicines.更多还原