【摘要】 目的:观察鞣酸蛋白酵母散治疗小儿急性腹泻的疗效及安全性。方法:选取急性腹泻患儿81例,按随机数字表法分为治疗组(41例)和对照组(40例)。两组患儿均给予常规治疗,治疗组患儿在常规治疗基础上口服鞣酸蛋白酵母散,对照组患儿在常规治疗基础上加用蒙脱石散治疗。观察两组患儿治疗后的临床疗效、药物口感及不良反应。结果:治疗组总有效率(97.56%)与对照组(100%)比较,差异无统计学意义(P>0.05);治疗后治疗组患儿排便次数和尿量评分均高于对照组,差异有统计学意义(P<0.05);治疗组患儿服用的鞣酸蛋白酵母散口感评分(2.93±0.35)明显高于对照组的蒙脱石散口感评分(1.25±0.44),差异有统计学意义(P<0.05);两组患儿均未见不良反应。结论:鞣酸蛋白酵母散与蒙脱石散治疗小儿急性腹泻的临床疗效及安全性均较好。但对于患儿食欲的改善及减轻腹痛方面鞣酸蛋白酵母散更优,服用时的口感更好,故患儿依从性更高。更多还原

【Abstract】 OBJECTIVE:To observe therapeutic efficacy and safety of Albumin tannate and barm powder in the treatment of infantile acute diarrhea. METHODS:81 cases of infantile acute diarrhea were selected and randomly divided into treatment(41 cases)and control group(40 cases). Both groups received routine treatment;treatment group was additionally given Albumin tannate and barm powder orally;control group was additionally given Montmorillonite powder. Clinical efficacy,the taste of drugs and ADR were observed in 2 groups after treatment. RESULTS:There was no statistical significance in total effective rate(97.56%)of treatment group and that(100%)of control group(P>0.05). After treatment,defecation times and urine volume score of treatment group were higher than those of control group,with statistical significance(P<0.05). The taste score of Albumin tannate and barm powder(2.93±0.35)in treatment group was significantly higher than(1.25±0.44)in control group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Albumin tannate and barm powder and Montmorillonite powder have good clinical efficacy and safety in the treatment of infantile acute diarrhea. Albumin tannate and barm powder is better than Montmorillonite powder in improving children’s appetite and relieving abdominal pain. Albumin tannate and barm powder tastes better when taking,gain a better adherence in the children patients.更多还原