【摘要】 目的:研究总丹参酮对模型大鼠疮疡的促愈合作用。方法:sc给予金黄色葡萄球菌悬液以复制大鼠疮疡模型。50只SD大鼠随机均分为正常对照[等容羧甲基纤维素钠(CMC-Na)溶液]组、模型(CMC-Na溶液)组、氨苄西林(阳性药物,20 mg/kg)组与总丹参酮高、低剂量(200、100 mg/kg)组,ig给药,每天1次,连续12 d。观察大鼠一般情况;测定给药12 d后大鼠血清中溶菌酶(LZM)和免疫球蛋白(Ig G)含量,测定给药4、8、12 d后大鼠脓性分泌物中LZM和Ig G含量;评定大鼠创面恶化积分。结果:与正常对照组比较,模型组大鼠各指标恶化。与模型组比较,总丹参酮高剂量组大鼠食欲增加,活动量增加,皮肤无分泌物,疮面洁净结痂;给药12 d后,总丹参酮高、低剂量组大鼠血清中LZM和Ig G含量增加;给药4、8、12 d后总丹参酮高、低剂量组大鼠脓性分泌物中LZM、Ig G含量增加;给药8、12 d后,总丹参酮高剂量组大鼠创面恶化积分降低,差异均有统计学意义(P<0.01或P<0.05)。结论:总丹参酮能促进模型大鼠疮疡的愈合,其机制与增加血清与脓性分泌物中LZM和Ig G含量有关。更多还原

【Abstract】 OBJECTIVE:To investigate the healing-promoting effect of total tanshinone on sore and ulcer of model rats.METHODS:Staphylococcus aureus levitation liquid was made to reproduce model rats with sore and ulcer,sc.50 rats were randomly divided into normal group(equal volume of CMC-Na solution),model group(equal volume of CMC-Na solution),ampicillin group(positive drug 20 mg/kg)and total tanshinone high and low dose groups(200 and 100 mg/kg),ig,once a day for continuous 12 d.The general conditions were observed.The content of lysozyme(LZM)and immunoglobulins G(Ig G)in serum were tested after 12 d;the content of LZM and Ig G in purulent secretion of model rats were respectively tested after dosing of 4 d,8 d and 12 d.The integral of wound deterioration were evaluated.RESULTS:Compared with normal control group,the index was worse in model group.Compared with model group,the appetite and activity amount of total tanshinone in high dose group(200 and 100mg/kg)were increased,with no secretion on the wound and a clean escharosis;content of LZM and Ig G in serum of rats in in total tanshinone high and low dose group were increased after 12 d;also,the content of LZM and Ig G in purulent secretion of rats in total tanshinone high and low dose groups were increased after dosing of 4 d,8 d,and 12 d;the integral of wound deterioration in total tanshinone high dose group were decreased after dosing of 8 d and 12 d,with significant difference(P<0.01 or P<0.05).CONCLUSIONS:Total tanshinone can promote the wound healing on sore and ulcer of model rats by a mechanism that is related to the content of LZM and Ig G in serum and purulent secretion.更多还原