【摘要】 目的:评价延长哌拉西林/他唑巴坦(PIP/TAZ)输注时间治疗复杂性尿路感染的疗效及安全性。方法:将我院于2012年10月-2014年10月收治的84例复杂性尿路感染患者按SPSS 15.0软件随机分组程序分为试验组和对照组各42例。试验组予以PIP/TAZ 4.5 g持续静脉泵入,q8 h,静脉泵入时间为3 h;对照组予以PIP/TAZ 4.5 g静脉滴注,q8 h,静脉滴注时间为30 min。两组均以7 d为1个疗程,观察实验室检查指标、降钙素原与血白细胞计数。结果:两组患者治疗后降钙素原均较治疗前明显下降,差异有统计学意义(P<0.05);且治疗后组间比较差异亦有统计学意义(P<0.05)。两组患者治疗后血白细胞计数均较治疗前明显下降,差异有统计学意义(P<0.05);但组间比较差异无统计学意义(P>0.05)。试验组的临床总有效率为85.4%,对照组的临床总有效率为63.4%,差异有统计学意义(P<0.05)。两组不良反应发生率均为2.4%,差异无统计学意义(P>0.05)。结论:延长PIP/TAZ输注时间治疗复杂性尿路感染疗效确切、安全性高。更多还原

【Abstract】 OBJECTIVE:To evaluate the efficacy and safety of prolonged administration time of piperacillin/tazobactam(PIP/TAZ)in the treatment of complicated urinary tract infections. METHODS:84 patients with complicated urinary tract infections in our hospital from Oct. 2012 to Oct. 2014 were randomly divided into test group(n=42) and control group(n=42) by SPSS15.0 software randomized program. The test group was given PIP/TAZ 4.5 g for 3 h,continuous iv,q8 h;control group was given PIP/TAZ 4.5 g for 30 min,continuous iv,q8 h. The course was 7 d. The laboratory parameters,procalcitonin and white blood cell count were observed. RESULTS:After treatment,the procalcitonin in 2 groups were significantly decreased,with significant difference(P<0.05);there was significant difference between 2 groups(P<0.05). Compared with before,the white blood cell count in 2 groups were significantly decreased,with significant difference(P<0.05);however,there was no significant difference between 2 groups(P>0.05). The total effective rat of test group was 85.4% and it of control group was 63.4%,with significant difference(P<0.05). The incidence of adverse reactions in 2 groups was 2.4%,with no significant difference(P>0.05).CONCLUSIONS:Prolonged PIP/TAZ administration time has accurate efficacy and highly safety in the treatment of complicated urinary tract infections.更多还原