【摘要】 目的:比较不同基因型与血药浓度之间的关系,为实行个体化用药方案提供参考。方法:采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)法检测癫痫患者CYP2D6*10的基因型,高效液相色谱法测定丙戊酸钠的血药浓度。结果:CC、CT、TT3种基因型基因分别占20.9%、24.4%、54.7%;3种基因型癫痫患者服用丙戊酸钠达稳态血药浓度后测得的血药浓度、标准化血药浓度之间差异无统计学意义(P>0.05)。结论:CYP2D6*10基因多态性对癫痫患者服用丙戊酸钠的血药浓度没有影响。更多还原

【Abstract】 OBJECTIVE:To compare the relationship between different genotype and serum concentration and provide reference for implementing individualized regimen. METHODS:Genotype of CYP2D6*10 in patients with epilepsy was determined by PCR-RFLP method,and blood drug concentration of sodium valproate was determined by HPLC. RESULTS:Distribution of CC,CT and TT gene were 20.9%,24.4% and 54.7%,respectively. There were significant differences among the blood drug concentration and standardization plasma concentration determined after steady-state plasma concentrations of sodium valproate in 3 types of patients with genotype epileptic(P>0.05). CONCLUSIONS:CYP2D6*10 gene polymorphism does not affect the serum concentration of sodium valproate administration in patients with epilepsy.更多还原