【摘要】 目的:为临床合理使用万古霉素提供参考。方法:分析和评价我院2011年1月-2013年5月122份使用万古霉素病历中血药浓度监测结果及相关用药信息。结果:122例患者中,有118例进行了病原学检查,查出革兰阳性球菌的有78例,占66.10%;万古霉素谷浓度监测129例/次,平均值为(11.4±6.5)mg/L;用药前后患者肌酐值未出现明显变化。结论:万古霉素使用时应当根据患者实际体质量计算给药剂量,根据肌酐清除率确定给药间隔时间。进行治疗药物监测的药师应与临床建立沟通机制,及时将监测结果和调整建议反馈给临床医师。更多还原

【Abstract】 OBJECTIVE:To provide reference for rational clinical use of vancomycin. METHODS:The blood concentration monitoring results of 122 patients used vancomycin and related information of drug use were analyzed and evaluated in our hospital from Jan. 2011 to May 2013. RESULTS:Among the 122 cases,118 patients conducted pathogen detection. Gram-positive cocci were found in 78 cases,accounting for 66.10%. Trough concentration monitoring of vancomycin was 129 cases/times,with the average as(11.4±6.5)mg/L. The level of creatinine did not change significantly before and after treatment. CONCLUSIONS:The dosage of vancomycin should be calculated according to the patients’ weight;and medication intervals should be decided according to the creatinine clearance rate. Pharmacists who conduct TDM monitoring need to establish a communication mechanism with the clinical department,feed back the monitoring results and adjustment advice to clinicians timely.更多还原