【摘要】 目的观察口服普萘洛尔治疗婴幼儿眼部血管瘤的有效性及安全性。方法 24位年龄1~10个月的眼部血管瘤患儿,排除使用普萘洛尔禁忌症后,按普萘洛尔2mg/kg/日剂量进行口服治疗,监测心率血压至少72小时后保持出院继续治疗并保持随访。每月复查肿块B超、血糖、心率及血压,观察评估血管瘤变化及处理不良反应,根据肿块大小及B超情况择期减量至1mg/kg/日维持量,治疗疗程为6~18个月,并对治疗效果进行评价。结果24位病人通过治疗后,23人外观肿块消失者,1人仍可见眼睑肿胀、可扪及肿块。效果评价为Ⅳ级者23人(23/24,95.83%),Ⅱ级者1人(1/24,4.17%)。所有病人服药期间未见明显心率及血压降低。随访中3位年龄小于3个月的患儿出现睡眠不安、肝功能异常及低血糖反应。结论对于婴幼儿眼部血管瘤,口服普萘洛尔是一种安全有效的治疗方法。更多还原

【Abstract】 Objective To observe the efficacy and safety of oral propranolol for treatment of infantile ocular hemangioma. Methods 24 patients aged 1 to 10 months with ocular hemangioma underwent oral propranolol treatment after excluding the contraindications. The mean dose was 2mg/kg/day and treatment went on at home after monitoring the heart rate and blood pressure for 72 hours in hospital. The patients were followed-up monthly and evaluated with ultrasound examination,blood glucose,heart rate,blood pressure and adverse effect. According to the tumor size and ultrasound,the dose reduced to 1mg/kg/day and the treatment continued for 6 to 18 months. Results 23 patients had no tumor in appearence,but 1 patient still had visible tumor. The treatment responses were considered scale Ⅳ(excellent)in23 patients(23/24,95.83%) and scale Ⅱ(moderate) in 1 patient(1/24,4.17%). No patients had bradycardia and hypotension and only 3 patients had sleep disturbance,liver dysfunction and hypoglycemia. Conclusions Oral propranolol is a safe and effective treatment for infantile ocular hemangioma.更多还原