【摘要】 目的:探讨冠状动脉慢血流患者的临床及其解剖结构的特点。方法:入选2013-01至2015-01于本院行冠状动脉造影检查,结果示血管无明显病变(狭窄<40%)但采用心肌梗死溶栓治疗临床试验(TIMI)血流计帧法,造影剂通过至少1支冠状动脉的帧数>27帧的56例患者为慢血流组,同期冠状动脉造影无明显狭窄且血流正常的患者55例作为对照组。统计多项实验室指标,利用多因素Logistic回归分析红细胞体积(MCV)与冠状动脉慢血流的相关性。结果:慢血流组的MCV[90.4(87.5,92.7)f L]、红细胞分布宽度变异系数[RDW-CV,12.5(12.3,13.2)%]显著低于对照组[92.3(90.1,94.3)f L、13.0(12.7,13.4)%,P<0.05];慢血流组的红细胞血红蛋白浓度[MCHC,337(332,347)g/L]、回旋支动脉的远端分支数[3(2,4)支]显著高于对照组[328(322,338)g/L、2(2,3)支,P<0.05]。多因素Logistic回归分析示,MCV与冠状动脉慢血流呈负相关(偏回归系数=-0.138,P=0.015)。两者的Spearman等级相关分析结果,MCV与冠状动脉血流帧数呈显著负相关(r=-0.201,P=0.009)。结论:红细胞变形可能参与了冠状动脉慢血流的病理生理过程。更多还原

【Abstract】 Objective: To explore the clinical and anatomical characteristics of coronary slow flow(CSF) in relevant patients. Methods: We summarized the patients without coronary angiography(CAG) proved coronary stenosis(stenosis < 40%) while with TIMI indicated CSF in our hospital from 2013-01 to 2015-01. The patients were divided into 2 groups: CSF group, n=56 patients having at least 1 major coronary artery with TIMI frame counts > 27 and Control group, n=55 patients with normal coronary flow. The related laboratory indexes were examined and relationship between MCV and CSF was studied by multi-logistic regression analysis. Results: In CSF group, MCV 90.4(87.48, 92.65) f L and RDW-CV 12.5(12.30, 13.18) % were lower than those in Control group 92.3(90.1, 94.3) f L and 13(12.7, 13.4) %, P<0.05; while MCHC 337(332, 347) g/L and the number of left circumflex distal braches involved 3(2, 4) were higher than those in Control group 327.5(322, 338) g/L and 2(2, 3), P<0.05. Multi-logistic regression analysis showed that MCV was negatively related to CSF(partial regression coefficient=-0.138, P=0.015), Spearman rank correlation analysis presented that MCV was negatively related to TIMI frame counts(r=-0.201, P=0.009).Conclusion: Deformability of red blood cells might be involved in pathogenesis of CSF in relevant patients.更多还原