【摘要】 目的:探讨体外循环(CPB)心脏直视手术患儿术中成分输血与术后预后的关系。方法:回顾性分析1 028例接受CPB心脏直视手术患儿的临床资料,采用单因素分析及多元Logistic回归分析探讨术中成分输血与术后院内死亡及并发症的关系。结果:1 028例患儿中,术后院内死亡45例(4.4%),发生低心排血量综合征143例(13.9%),急性肾功能衰竭43例(4.2%),肺衰竭26例(2.5%),感染17例(1.7%),神经系统并发症28例(2.7%)。多元Logistic回归分析显示,术后院内死亡的独立危险因素为CPB时间、CPB最低温度、术后24 h儿童死亡风险(PRISM-Ⅲ)评分及术中红细胞输注量>中位输注量(20.3 ml/kg),而术后并发症的独立危险因素为紫绀型先天性心脏病、CPB时间、术后24 h PRISM-Ⅲ评分、术后6 h纵膈引流量及术中红细胞输注量>20.3 ml/kg。结论:儿童CPB心脏直视手术中输注大量红细胞增加术后院内死亡及并发症风险,减少术中红细胞输注可能会改善先天性心脏病儿童的术后预后。更多还原

【Abstract】 Objective: To explore the relationship between intra-operative blood product transfusion and post-operative prognosis in children with pediatric open heart surgery by cardiopulmonary bypass(CPB).Methods: A total of 1028 consecutive pediatric patients received the open heart surgery by CPB in our hospital were retrospectively studied. Uni- and multivariate Logistic regression analysis were conducted to analyze the relationship between intra-operative blood product transfusion and post-operative in-hospital death and complication rates.Results: There were 45/1028(4.4%) of patients died, 143(13.9%) with low cardiac output syndrome, 43(4.2%) received dialysis, 26(2.5%) with sustained pulmonary failure, 17(1.7%) with infection, and 28(2.7%) developed neurologic complications. Multivariate Logistic regression analysis indicated that duration and the lowest temperature of CPB, 24-hour post-operative pediatric risk of mortality(PRISM-III) score and intra-operative transfusion amount of RBC > median(20.3 ml/kg) were the independent risk factors for post-operative in-hospital death. Congenital heart disease(CHD) with pre-operative cyanosis, duration of CPB, 24-hour post-operative PRISM-III score, 6-hour post-operative mediastinal drain loss and intra-operative transfusion amount of RBC > 20.3 ml/kg were the independent risk factors for post-operative complication occurrence.Conclusion: Large volume of RBC transfusion in the open heart pediatric surgery with CPB may increase the risk of post-operative in-hospital death and complication occurrence, reducing RBC transfusion might be improving the post-operative prognosis in CHD patients.更多还原