【摘要】 目的探讨石杉碱甲联合尼麦角林治疗血管性痴呆的临床效果。方法从我院2011年3月~2015年3月收治的血管性痴呆患者中随机选取92例进行研究,并按照随机数字表法分为对照组(46例,经石杉碱甲治疗)和观察组(46例,经石杉碱甲联合尼麦角林治疗),比较两组患者的临床效果,治疗前后的MMSE、ADL、ESS和HDS-R评分和不良反应情况。结果对照组的总有效率为63.04%,明显低于观察组的86.96%(P<0.05)。治疗后,两组患者的MMSE、ADL、ESS和HDS-R评分均明显改善,且观察组的以上评分均明显高于对照组(P<0.05)。两组患者在治疗过程中均有6例出现轻度腹部不适、恶心呕吐、头晕等症状,均自行缓解,不影响研究结果,组间不良反应发生情况差异无统计学意义(P>0.05)。结论石杉碱甲联合尼麦角林治疗血管性痴呆的效果显著,可有效改善患者的认知状态和生活质量,具有较高的临床应用价值。更多还原

【Abstract】 Objective To explore the clinical effect of huperzine A combined with nicergolent treating vasculardementia.Methods 92 patients with vasculardementia from March 2011 to March 2015 were randomly selected from our hospital to study.Patients were divided into control group(46 cases and was treated with huperzine A)and observation group(46 cases and was treated with huperzine A combined with nicergolent)according to random number table method.Clinical effect,MMSE,ADL,ESS,HDS-Rscore before and after treatment and adverse reaction between two groups was compared respectively.Results The total effective was 63.04% in control group,which was obvious lower than that was 86.96% in observation group(P<0.05).After treatment,MMSE,ADL,ESS,HDS-Rscore was increased in two groups,and above-mentioned score in observation group was obviously higher than that of control group respectively(P<0.05).During treatment,each group had 6 patients appeared light abdominal discomfort,nausea and vomiting and dizzinesswhich alleviated by itself and had no impact on results,and the difference of adverse reaction between two groups had no statistical significance(P>0.05).Conclusion Huperzine A combined with nicergolent treating vasculardementia has effective effect.It can effectively improve cognitive status and life quality of patients and it has higher clinical application value.更多还原