【摘要】 目的分析利培酮治疗自闭症谱系障碍的临床疗效。方法选取2012年4月~2014年3月本院收治的82例自闭症谱系障碍患儿为研究对象,将其随机分为观察组与对照组,每组41例。对照组患儿接受常规教育和康复训练,实验组患儿在此基础上辅以利培酮治疗。连续治疗12周,以治疗前后两组患儿自闭症治疗评定(ATEC)量表评分的变化评价其疗效,分析利培酮治疗后的效果和不良反应。结果治疗后对照组患儿ATEC评分由(112.35±15.21)分下降至(85.36±10.18)分,实验组患儿ATEC评分由(112.48±15.33)分下降至(73.45±9.71)分,实验组患儿ATEC评分下降幅度明显大于对照组,差异有统计学意义(P<0.05)。治疗期间对照组患儿未见不良反应,实验组患儿出现嗜睡3例、肌张力升高2例、心动过速2例,实验组患儿不良反应发生率明显高于对照组,差异有统计学意义(P<0.05)。结论在常规教育和康复训练的基础上辅以利培酮治疗自闭症谱系障碍具有满意的临床疗效,有助于改善患儿语言、社交、感知觉、行为等,具有积极的临床意义,治疗期间应重视处理不良反应。更多还原

【Abstract】 Objective To analyze the clinical efficacy of risperidone in the treatment of autistic spectrum disorder.Methods 82 children with autistic spectrum disorders from April 2012 to March 2014 in our hospital were selected as research subjects,and divided them randomly into observation group and control group,with 41 cases in each group.Children in control group received conventional education and rehabilitation,and children in the experimental group received education and rehabilitation plus risperidone.After 12-weeks continuous therapy,based on the changing evaluation effects of autism rating scale(ATEC) before and after treatment,the effectiveness and adverse effects of risperidone treatment was analyzed. Results After treatment,ATEC score of children in control group decreased from(112.35 ±15.21) points to(85.36±10.18) points,and ATEC score of children in experimental group decreased from(112.48±15.33)points to(73.45±9.71) points.The decrease of ATEC score of children in the experimental group was greater than that in control group,with statistical difference(P <0.05).There was no evidence of adverse reactions in control group during treatment,and children in experimental group presented three cases of drowsiness,two cases of increased muscle tension and two cases of tachycardia.The ratio of adverse reactions in experimental group was greater than that in control group,with statistical difference(P<0.05). Conclusion The treatment of conventional education and rehabilitation plus risperidone autism for spectrum disorders shows satisfactory clinical efficacy,for this method helps improve children language,socialization,perception and behavior and so on.This treatment shows positive clinical efficacy,and attention should be paid to adverse reactions during treatment.更多还原