【摘要】 目的探讨核素骨显像预测99Tc-MDP治疗类风湿关节炎效果的临床价值。方法 2012年6月~2014年10月,选取诊断明确的39例活动性类风湿关节炎患者在99Tc-MDP治疗前采用放射性核素骨骼显像剂(99m Tc-MDP)对病变关节进行显像,利用感兴趣区(ROI)技术计算病变关节摄取比值(T/N)。99Tc-MDP治疗前及治疗后6周记录患者的关节压痛数、关节肿胀数、晨僵时间,红细胞沉降率(ESR)、C反应蛋白(CRP),将患者分为显效组、有效组及无效组,比较3组的T/N值,同时按T/N值分为高摄取、低摄取组,并进行疗效比较。结果不同疗效组的T/N值差异有统计学意义(P<0.05),显效组的T/N值最高,无效组的T/N值最低。高摄取、低摄取组的疗效差异有统计学意义,高摄取组的疗效优于低摄取组(P<0.05)。结论核素骨显像在预测99Tc-MDP治疗类风湿关节炎效果方面有较高的临床价值,对临床医师优化治疗方案有很好的指导作用。更多还原

【Abstract】 Objective To explore the clinical value of nuclide bone imaging forecasting the effect of99Tc-MDP treating rheumatoid arthritis. Methods From June 2012 to October 2014,39 patients with active rheumatoid arthritis diagnosed clearly were taken images for affected joints by radionuclide bone imaging agent(99mTc-MDP) before99Tc-MDP treatment.The uptake ratio(T/N) of affected joints was calculated by region of interest(ROI) technique.Before99Tc-MDP treatment and after 6-week therapy,joint tenderness number,joint swelling number,time of morning stiffness,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP) were recorded.They were divided into effective markedly group,effective group and ineffective group.T/N value among three groups was compared.According to T/N value,they were divided into high uptake group and low uptake group,in which the therapeutic effect was compared. Results There was a statistical difference of T/N value in different therapeutic group(P<0.05),and T/N value in effective markedly group was highest,and lowest in the ineffective group.There was a statistical difference of curative effect between high uptake group and low uptake group,and the curative effect in high uptake group was better than that of low uptake group(P<0.05). Conclusion Nuclide bone imaging has higher clinical value in forecasting effect of99Tc-MDP treating rheumatoid arthritis and has a better guidance role for clinicians optimizing therapeutic regimen.更多还原