【摘要】 目的探讨血必净对恙虫病并发多器官功能障碍患者的保护作用。方法选取2009年2月~2013年8月本院收治的56例恙虫病并发多器官功能障碍患者作为研究对象,随机分为对照组与观察组。对照组给予常规疗法,实施对症治疗与器官支持治疗;观察组在对照组的基础上给予血必净注射液治疗。比较两组治疗前后的血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、内毒素(LPS)、肿瘤坏死因子(TNF)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、氧合指数(Pa O2/Fi O2)、凝血酶原时间(PT)、部分凝血酶原时间(APTT)、血小板(PLT)、急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分水平变化。结果观察组的治愈率显著高于对照组,差异有统计学意义(P<0.05)。观察组治疗后的Pa O2/Fi O2、AST、ALT、APTT、PLT、APACHEⅡ水平显著优于治疗前及对照组治疗后,差异有统计学意义(P<0.05)。观察组治疗后的LPS、TNF、IL-6、IL-8水平显著低于治疗前,差异有统计学意义(P<0.05)。观察组治疗后的LPS、TNF水平显著低于对照组治疗后,差异有统计学意义(P<0.05)。结论血必净能够提高恙虫病并发多器官功能障碍患者的治愈率,并通过减少炎症介质分泌来实现对多器官功能障碍的保护作用。更多还原

【Abstract】 Objective To explore the protective effect of Xuebijing on patient with tsutsugamushi disease combined with multiple organ dysfunction syndrome. Methods 56 cases with sutsugamushi disease combined with multiple organ dysfunction syndrome from February 2009 to August 2013 in our hospital were selected and randomly divided into the control group and the observation group.The control group was given routine therapy,symptomatic treatment and organ support therapy,the observation group was treated with Xuebijing injection on the basis of the control group.The level of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),endotoxin(LPS),tumor necrosis factor(TNF),interleukin-6(IL-6),interleukin-8(IL-8),oxygenation index(Pa O2/Fi O2),prothrombin time(PT),partial thromboplastin time(APTT),platelet(PLT),the acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) in two groups was compared respectively. Results The cure rate in the observation group was higher than that in the control group,with significant difference(P <0.05).The level of Pa O2/Fi O2,AST,ALT,APTT、PLT,APACHE Ⅱ in the observation group after treatment was better than that before treatment and the control group after treatment,with significant difference(P<0.05).The level of LPS,TNF,IL-6,IL-8 in the observation group after treatment was lower than that before treatment,with significant difference(P<0.05).The level of LPS,TNF in the observation group after treatment was lower than in the control group after treatment,with significant difference(P<0.05). Conclusion Xuebijing can improve the cure rate of patient with tsutsugamushi disease combined with multiple organ dysfunction syndrome,and which has protective effect on multiple organ dysfunction syndrome by reducing the secretion of inflammatory mediator.更多还原