【摘要】 目的探讨肠内、肠外序贯营养支持对重症颅脑损伤患者肠黏膜屏障的影响。方法选择2011年8月~2014年8月入院的90例重症颅脑损伤患者为研究对象,随机分为两组,观察组(n=45)行肠内、肠外序贯营养支持,对照组(n=45)行单纯肠内营养支持。对比两组血浆谷氨酰胺、白蛋白水平,甘露醇/乳果糖(L/M)比值,并发症及预后。结果营养支持10 d后,观察组血浆谷氨酰胺及白蛋白水平明显高于对照组(P<0.05),L/M比值明显低于对照组(P<0.01);观察组并发症发生率及死亡率明显低于对照组,差异有统计学意义(P<0.01)。结论由肠外营养序贯过渡至肠内营养,可有效改善重症颅脑损伤患者肠黏膜屏障功能,更好地预防感染、改善机体营养。更多还原

【Abstract】 Objective To investigate influence of enteral and parenteral nutrition sequential support on intestinal mucosal barrier of patients with severe craniocerebral injury. Methods 90 patients with severe craniocerebral injury in our hospital from August 2011 to August 2014 were selected and randomly divided into two groups.The enteral and parenteral sequential nutrition support were used in observation group(n=45),the enteral nutrition support was applied in control group(n =45).The plasma glutamine,albumin level,lactulose/mannitol(L/M)ratio,complication and prognosis between two groups were contrasted. Results After 10 d of nutrition support,the plasma glutamine and albumin level of observation group was significantly higher than that of control group respectively(P<0.05),the L/M ratio of observation group was lower than that of control group(P <0.01).Incidence rate of complication and mortality rate of observation group was lower than that of control group respectively,with statistical difference(P<0.01). Conclusion Parenteral nutrition sequential transition to enteral nutrition can improve the intestinal barrier function in patients with severe craniocerebral injury,better to prevent infection and improve the body′s nutrition.更多还原