【摘要】 目的探讨0.1%他克莫司软膏治疗唇炎的临床效果。方法选择2013年4月~2014年3月本院就诊的36例唇炎患者作为观察对象,外涂0.1%他克莫司软膏,早晚各1次,7 d为1个疗程,连续使用2个疗程。另设30例作对照,外涂丁酸氢化可的松软膏,早晚各1次,7 d为1个疗程,连续使用2个疗程。结果他克莫司组的总有效率为94.4%,明显高于丁酸氢化可的松组(80.0%),差异有统计学意义(P<0.05);治疗结束后进行了3个月的随访发现,他克莫司组中4例患者复发,复发率为11.1%,丁酸氢化可的松组中有8例患者复发,复发率为26.7%,他克莫司组的复发率显著低于丁酸氢化可的松组,差异有统计学意义(P<0.05)。结论 0.1%他克莫司软膏治疗唇炎的效果显著,复发率低,值得临床推广应用。更多还原

【Abstract】 Objective To explore the clinical effect of 0.1% tacrolimus ointment in the treatment of cheilitis. Methods36 patients with cheilitis treated in our hospital from April 2013 to March 2014 were selected as the observation objects.0.1% tacrolimus ointment was coated outside once every morning and evening and a course of treatment was seven days,and this drug was continuously used for 2 courses.Another 30 cases were selected as the control group,and hydrocortisone butyrate ointment was coated outside once every morning and evening and a course of treatment was seven days,and this drug was continuously used for 2 courses. Results The total effective rate in the tacrolimus ointment group(94.4%) was significantly higher than that of the hydrocortisone butyrate group(80.0%) with statistical difference(P < 0.05).Patients were followed up for 3 months after treatment,4 patients in the tacrolimus ointment had recurrence and the recurrence rate was 11.1%. 8 cases of patients in the hydrocortisone butyrate group had recurrence and the recurrence rate was 26.7%,the recurrence rate in the tacrolimus ointment group was significantly lower than that of hydrocortisone butyrate group with statistical difference(P<0.05). Conclusion 0.1% tacrolimus ointment in the treatment of cheilitis had obvious curative effect and low recurrence rate and it is worthy of clinical promotion and application.更多还原